TIP60 in aging and neurodegeneration

Research output: Contribution to journal › Review › Research › peer-review

Standard

TIP60 in aging and neurodegeneration. / Li, Zhiquan; Rasmussen, Lene Juel.

In: Ageing Research Reviews, Vol. 64, 101195, 2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Li, Z & Rasmussen, LJ 2020, 'TIP60 in aging and neurodegeneration', Ageing Research Reviews, vol. 64, 101195. https://doi.org/10.1016/j.arr.2020.101195

APA

Li, Z., & Rasmussen, L. J. (2020). TIP60 in aging and neurodegeneration. Ageing Research Reviews, 64, [101195]. https://doi.org/10.1016/j.arr.2020.101195

Vancouver

Li Z, Rasmussen LJ. TIP60 in aging and neurodegeneration. Ageing Research Reviews. 2020;64. 101195. https://doi.org/10.1016/j.arr.2020.101195

Author

Li, Zhiquan ; Rasmussen, Lene Juel. / TIP60 in aging and neurodegeneration. In: Ageing Research Reviews. 2020 ; Vol. 64.

Bibtex

@article{8545ad5e54d34cc4a4f0adcc36a3cf24,
title = "TIP60 in aging and neurodegeneration",
abstract = "Epigenetic modification of chromatin, including histone methylation and acetylation, plays critical roles in eukaryotic cells and has a significant impact on chromatin structure/accessibility, gene regulation and, susceptibility to aging, neurodegenerative disease, cancer, and other age-related diseases. This article reviews the current advances on TIP60/KAT5, a major histone acetyltransferase with diverse functions in eukaryotes, with emphasis on its regulation of autophagy, proteasome-dependent protein turnover, RNA transcription, DNA repair, circadian rhythms, learning and memory, and other neurological functions implicated in aging and neurodegeneration. Moreover, the promising therapeutic potential of TIP60 is discussed to target Alzheimer's disease and other neurological diseases.",
keywords = "Acetylation, Alzheimer's disease, Autophagy, Gene expression, Genome instability, Memory",
author = "Zhiquan Li and Rasmussen, {Lene Juel}",
year = "2020",
doi = "10.1016/j.arr.2020.101195",
language = "English",
volume = "64",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - TIP60 in aging and neurodegeneration

AU - Li, Zhiquan

AU - Rasmussen, Lene Juel

PY - 2020

Y1 - 2020

N2 - Epigenetic modification of chromatin, including histone methylation and acetylation, plays critical roles in eukaryotic cells and has a significant impact on chromatin structure/accessibility, gene regulation and, susceptibility to aging, neurodegenerative disease, cancer, and other age-related diseases. This article reviews the current advances on TIP60/KAT5, a major histone acetyltransferase with diverse functions in eukaryotes, with emphasis on its regulation of autophagy, proteasome-dependent protein turnover, RNA transcription, DNA repair, circadian rhythms, learning and memory, and other neurological functions implicated in aging and neurodegeneration. Moreover, the promising therapeutic potential of TIP60 is discussed to target Alzheimer's disease and other neurological diseases.

AB - Epigenetic modification of chromatin, including histone methylation and acetylation, plays critical roles in eukaryotic cells and has a significant impact on chromatin structure/accessibility, gene regulation and, susceptibility to aging, neurodegenerative disease, cancer, and other age-related diseases. This article reviews the current advances on TIP60/KAT5, a major histone acetyltransferase with diverse functions in eukaryotes, with emphasis on its regulation of autophagy, proteasome-dependent protein turnover, RNA transcription, DNA repair, circadian rhythms, learning and memory, and other neurological functions implicated in aging and neurodegeneration. Moreover, the promising therapeutic potential of TIP60 is discussed to target Alzheimer's disease and other neurological diseases.

KW - Acetylation

KW - Alzheimer's disease

KW - Autophagy

KW - Gene expression

KW - Genome instability

KW - Memory

U2 - 10.1016/j.arr.2020.101195

DO - 10.1016/j.arr.2020.101195

M3 - Review

C2 - 33091598

AN - SCOPUS:85096172039

VL - 64

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

M1 - 101195

ER -

ID: 251938886