Thrombolysis in acute ischemic stroke is associated with lower long-term hospital bed day use: A nationwide propensity score-matched follow-up study
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Thrombolysis in acute ischemic stroke is associated with lower long-term hospital bed day use : A nationwide propensity score-matched follow-up study. / Terkelsen, Thorkild; Schmitz, Marie Louise; Simonsen, Claus Z; Hundborg, Heidi Holmager; Christensen, Hanne K; Gyllenborg, Jesper; Sandal, Birgitte F; Iversen, Helle K; Madsen, Charlotte; Rasmussen, Mary-Jette; Vestergaard, Karsten; Andersen, Grethe; Johnsen, Søren P.
In: International Journal of Stroke, Vol. 11, No. 8, 2016, p. 910-916.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Thrombolysis in acute ischemic stroke is associated with lower long-term hospital bed day use
T2 - A nationwide propensity score-matched follow-up study
AU - Terkelsen, Thorkild
AU - Schmitz, Marie Louise
AU - Simonsen, Claus Z
AU - Hundborg, Heidi Holmager
AU - Christensen, Hanne K
AU - Gyllenborg, Jesper
AU - Sandal, Birgitte F
AU - Iversen, Helle K
AU - Madsen, Charlotte
AU - Rasmussen, Mary-Jette
AU - Vestergaard, Karsten
AU - Andersen, Grethe
AU - Johnsen, Søren P
PY - 2016
Y1 - 2016
N2 - Background Thrombolysis with intravenous recombinant tissue-type plasminogen activator improves functional outcome in acute ischemic stroke. Few studies have investigated the effects of thrombolysis in a real-world setting. We evaluated the impact of thrombolysis on long-term hospital bed day use and the risk of readmission due to stroke-related complications. Methods We conducted a register-based nationwide propensity score-matched follow-up study among ischemic stroke patients in Denmark (2004-2011). Thrombolysed patients were propensity-score matched with non-thrombolysed acute ischemic stroke patients admitted to stroke centers not yet offering thrombolysis in 2004-2006. The outcomes were length of the stroke admission, total all-cause hospital bed day use during the first year after the stroke, and the long-term risk of readmissions. Thrombolysed and non-thrombolysed patients were compared using multivariable log-linear regression and Cox regression. Results We identified 1095 thrombolysed and 1095 propensity score matched eligible but non-thrombolysed acute ischemic stroke patients. The median length of the stroke admission was 9 days in the thrombolysed group and 13 days in the non-thrombolysed group (adjusted geometric mean ratio, 0.88; 95% CI: 0.78-1.00). The median all-cause hospital bed day use within the first year was 12 days in the thrombolysed group and 19 days in the non-thrombolysed group (adjusted geometric mean ratio, 0.82; 95% CI: 0.73-0.92). There was no significant difference in the overall risk of readmission (adjusted hazard ratio, 0.91; 95% CI: 0.79-1.04); however, thrombolysis was associated with reduced risk of pneumonia (adjusted hazard ratio, 0.59; 95% CI: 0.35-0.97). Conclusions Thrombolysis in ischemic stroke was associated with lower long-term hospital bed day use and decreased risk of readmission due to pneumonia.
AB - Background Thrombolysis with intravenous recombinant tissue-type plasminogen activator improves functional outcome in acute ischemic stroke. Few studies have investigated the effects of thrombolysis in a real-world setting. We evaluated the impact of thrombolysis on long-term hospital bed day use and the risk of readmission due to stroke-related complications. Methods We conducted a register-based nationwide propensity score-matched follow-up study among ischemic stroke patients in Denmark (2004-2011). Thrombolysed patients were propensity-score matched with non-thrombolysed acute ischemic stroke patients admitted to stroke centers not yet offering thrombolysis in 2004-2006. The outcomes were length of the stroke admission, total all-cause hospital bed day use during the first year after the stroke, and the long-term risk of readmissions. Thrombolysed and non-thrombolysed patients were compared using multivariable log-linear regression and Cox regression. Results We identified 1095 thrombolysed and 1095 propensity score matched eligible but non-thrombolysed acute ischemic stroke patients. The median length of the stroke admission was 9 days in the thrombolysed group and 13 days in the non-thrombolysed group (adjusted geometric mean ratio, 0.88; 95% CI: 0.78-1.00). The median all-cause hospital bed day use within the first year was 12 days in the thrombolysed group and 19 days in the non-thrombolysed group (adjusted geometric mean ratio, 0.82; 95% CI: 0.73-0.92). There was no significant difference in the overall risk of readmission (adjusted hazard ratio, 0.91; 95% CI: 0.79-1.04); however, thrombolysis was associated with reduced risk of pneumonia (adjusted hazard ratio, 0.59; 95% CI: 0.35-0.97). Conclusions Thrombolysis in ischemic stroke was associated with lower long-term hospital bed day use and decreased risk of readmission due to pneumonia.
U2 - 10.1177/1747493016654491
DO - 10.1177/1747493016654491
M3 - Journal article
C2 - 27312677
VL - 11
SP - 910
EP - 916
JO - International Journal of Stroke
JF - International Journal of Stroke
SN - 1747-4930
IS - 8
ER -
ID: 176898781