Thermotropic liquid crystalline drugs

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Thermotropic liquid crystalline drugs. / Bunjes, Heike; Rades, Thomas.

In: Journal of Pharmacy and Pharmacology, Vol. 57, No. 7, 2005, p. 807-16.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bunjes, H & Rades, T 2005, 'Thermotropic liquid crystalline drugs', Journal of Pharmacy and Pharmacology, vol. 57, no. 7, pp. 807-16. https://doi.org/10.1211/0022357056208

APA

Bunjes, H., & Rades, T. (2005). Thermotropic liquid crystalline drugs. Journal of Pharmacy and Pharmacology, 57(7), 807-16. https://doi.org/10.1211/0022357056208

Vancouver

Bunjes H, Rades T. Thermotropic liquid crystalline drugs. Journal of Pharmacy and Pharmacology. 2005;57(7):807-16. https://doi.org/10.1211/0022357056208

Author

Bunjes, Heike ; Rades, Thomas. / Thermotropic liquid crystalline drugs. In: Journal of Pharmacy and Pharmacology. 2005 ; Vol. 57, No. 7. pp. 807-16.

Bibtex

@article{69e6fc48ed8d4428898346754ccc6ef0,
title = "Thermotropic liquid crystalline drugs",
abstract = "Crystalline solids are characterized by long-range positional and orientational order in three dimensions, whereas amorphous liquids lack long-range order in any dimension. Liquid crystals (mesophases) show structural, mechanical and optical properties intermediate to those of crystalline solids and the amorphous, liquid state of matter. There are two principle types of liquid crystals: thermotropic liquid crystals (TLCs) and lyotropic liquid crystals (LLCs). TLCs can be formed by heating a crystalline solid or by cooling an isotropic melt of a TLC-forming molecule (mesogen). In the first part of this review the types of liquid crystals are defined and classified and the structural properties of mesogens are explained. In the second part, ten case studies of thermotropic mesomorphous drugs and pharmaceutically relevant molecules (arsphenamine, nafoxidine hydrochloride, L-660711, palmitoyl propranolol hydrochloride, penbutolol sulfate, itraconazole hydrochloride, fenoprofen sodium, fenoprofen calcium, ciclosporin and cholesteryl esters) are presented and their thermotropic mesomorphism is described. The review closes with a brief discussion of the unusual properties of drug mesophases and a potential use of drugs and excipients in this fourth state of matter.",
keywords = "Crystallization, Drug Design, Solubility, Structure-Activity Relationship, Temperature",
author = "Heike Bunjes and Thomas Rades",
year = "2005",
doi = "10.1211/0022357056208",
language = "English",
volume = "57",
pages = "807--16",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "JohnWiley & Sons Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Thermotropic liquid crystalline drugs

AU - Bunjes, Heike

AU - Rades, Thomas

PY - 2005

Y1 - 2005

N2 - Crystalline solids are characterized by long-range positional and orientational order in three dimensions, whereas amorphous liquids lack long-range order in any dimension. Liquid crystals (mesophases) show structural, mechanical and optical properties intermediate to those of crystalline solids and the amorphous, liquid state of matter. There are two principle types of liquid crystals: thermotropic liquid crystals (TLCs) and lyotropic liquid crystals (LLCs). TLCs can be formed by heating a crystalline solid or by cooling an isotropic melt of a TLC-forming molecule (mesogen). In the first part of this review the types of liquid crystals are defined and classified and the structural properties of mesogens are explained. In the second part, ten case studies of thermotropic mesomorphous drugs and pharmaceutically relevant molecules (arsphenamine, nafoxidine hydrochloride, L-660711, palmitoyl propranolol hydrochloride, penbutolol sulfate, itraconazole hydrochloride, fenoprofen sodium, fenoprofen calcium, ciclosporin and cholesteryl esters) are presented and their thermotropic mesomorphism is described. The review closes with a brief discussion of the unusual properties of drug mesophases and a potential use of drugs and excipients in this fourth state of matter.

AB - Crystalline solids are characterized by long-range positional and orientational order in three dimensions, whereas amorphous liquids lack long-range order in any dimension. Liquid crystals (mesophases) show structural, mechanical and optical properties intermediate to those of crystalline solids and the amorphous, liquid state of matter. There are two principle types of liquid crystals: thermotropic liquid crystals (TLCs) and lyotropic liquid crystals (LLCs). TLCs can be formed by heating a crystalline solid or by cooling an isotropic melt of a TLC-forming molecule (mesogen). In the first part of this review the types of liquid crystals are defined and classified and the structural properties of mesogens are explained. In the second part, ten case studies of thermotropic mesomorphous drugs and pharmaceutically relevant molecules (arsphenamine, nafoxidine hydrochloride, L-660711, palmitoyl propranolol hydrochloride, penbutolol sulfate, itraconazole hydrochloride, fenoprofen sodium, fenoprofen calcium, ciclosporin and cholesteryl esters) are presented and their thermotropic mesomorphism is described. The review closes with a brief discussion of the unusual properties of drug mesophases and a potential use of drugs and excipients in this fourth state of matter.

KW - Crystallization

KW - Drug Design

KW - Solubility

KW - Structure-Activity Relationship

KW - Temperature

U2 - 10.1211/0022357056208

DO - 10.1211/0022357056208

M3 - Journal article

C2 - 15969938

VL - 57

SP - 807

EP - 816

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 7

ER -

ID: 40357664