Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

Research output: Contribution to journalJournal articlepeer-review

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Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task. / Fitzpatrick, C. M.; Caballero-Puntiverio, M.; Gether, U.; Habekost, T.; Bundesen, C.; Vangkilde, S.; Woldbye, D. P. D.; Andreasen, J. T.; Petersen, A.

In: Psychopharmacology, Vol. 234, No. 5, 2017, p. 845-855.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Fitzpatrick, CM, Caballero-Puntiverio, M, Gether, U, Habekost, T, Bundesen, C, Vangkilde, S, Woldbye, DPD, Andreasen, JT & Petersen, A 2017, 'Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task', Psychopharmacology, vol. 234, no. 5, pp. 845-855. https://doi.org/10.1007/s00213-016-4520-6

APA

Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, U., Habekost, T., Bundesen, C., Vangkilde, S., Woldbye, D. P. D., Andreasen, J. T., & Petersen, A. (2017). Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task. Psychopharmacology, 234(5), 845-855. https://doi.org/10.1007/s00213-016-4520-6

Vancouver

Fitzpatrick CM, Caballero-Puntiverio M, Gether U, Habekost T, Bundesen C, Vangkilde S et al. Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task. Psychopharmacology. 2017;234(5):845-855. https://doi.org/10.1007/s00213-016-4520-6

Author

Fitzpatrick, C. M. ; Caballero-Puntiverio, M. ; Gether, U. ; Habekost, T. ; Bundesen, C. ; Vangkilde, S. ; Woldbye, D. P. D. ; Andreasen, J. T. ; Petersen, A. / Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task. In: Psychopharmacology. 2017 ; Vol. 234, No. 5. pp. 845-855.

Bibtex

@article{cc14bbf0fc7449c6bf392a2a19e447f8,
title = "Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task",
abstract = "RationaleThe 5-choice serial reaction time task (5-CSRTT) is widely used to measure rodent attentional functions. In humans, many attention studies in healthy and clinical populations have used testing based on Bundesen{\textquoteright}s Theory of Visual Attention (TVA) to estimate visual processing speeds and other parameters of attentional capacity.ObjectivesWe aimed to bridge these research fields by modifying the 5-CSRTT{\textquoteright}s design and by mathematically modelling data to derive attentional parameters analogous to human TVA-based measures.MethodsC57BL/6 mice were tested in two 1-h sessions on consecutive days with a version of the 5-CSRTT where stimulus duration (SD) probe length was varied based on information from previous TVA studies. Thereafter, a scopolamine hydrobromide (HBr; 0.125 or 0.25 mg/kg) pharmacological challenge was undertaken, using a Latin square design. Mean score values were modelled using a new three-parameter version of TVA to obtain estimates of visual processing speeds, visual thresholds and motor response baselines in each mouse.ResultsThe parameter estimates for each animal were reliable across sessions, showing that the data were stable enough to support analysis on an individual level. Scopolamine HBr dose-dependently reduced 5-CSRTT attentional performance while also increasing reward collection latency at the highest dose. Upon TVA modelling, scopolamine HBr significantly reduced visual processing speed at both doses, while having less pronounced effects on visual thresholds and motor response baselines.ConclusionsThis study shows for the first time how 5-CSRTT performance in mice can be mathematically modelled to yield estimates of attentional capacity that are directly comparable to estimates from human studies.",
keywords = "Attention, Theory of Visual Attention, 5-choice serial reaction time task, Mouse behaviour, Attention deficit/hyperactivity disorder, Touchscreen operant chamber, Translatable animal models",
author = "Fitzpatrick, {C. M.} and M. Caballero-Puntiverio and U. Gether and T. Habekost and C. Bundesen and S. Vangkilde and Woldbye, {D. P. D.} and Andreasen, {J. T.} and A. Petersen",
year = "2017",
doi = "10.1007/s00213-016-4520-6",
language = "English",
volume = "234",
pages = "845--855",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

AU - Fitzpatrick, C. M.

AU - Caballero-Puntiverio, M.

AU - Gether, U.

AU - Habekost, T.

AU - Bundesen, C.

AU - Vangkilde, S.

AU - Woldbye, D. P. D.

AU - Andreasen, J. T.

AU - Petersen, A.

PY - 2017

Y1 - 2017

N2 - RationaleThe 5-choice serial reaction time task (5-CSRTT) is widely used to measure rodent attentional functions. In humans, many attention studies in healthy and clinical populations have used testing based on Bundesen’s Theory of Visual Attention (TVA) to estimate visual processing speeds and other parameters of attentional capacity.ObjectivesWe aimed to bridge these research fields by modifying the 5-CSRTT’s design and by mathematically modelling data to derive attentional parameters analogous to human TVA-based measures.MethodsC57BL/6 mice were tested in two 1-h sessions on consecutive days with a version of the 5-CSRTT where stimulus duration (SD) probe length was varied based on information from previous TVA studies. Thereafter, a scopolamine hydrobromide (HBr; 0.125 or 0.25 mg/kg) pharmacological challenge was undertaken, using a Latin square design. Mean score values were modelled using a new three-parameter version of TVA to obtain estimates of visual processing speeds, visual thresholds and motor response baselines in each mouse.ResultsThe parameter estimates for each animal were reliable across sessions, showing that the data were stable enough to support analysis on an individual level. Scopolamine HBr dose-dependently reduced 5-CSRTT attentional performance while also increasing reward collection latency at the highest dose. Upon TVA modelling, scopolamine HBr significantly reduced visual processing speed at both doses, while having less pronounced effects on visual thresholds and motor response baselines.ConclusionsThis study shows for the first time how 5-CSRTT performance in mice can be mathematically modelled to yield estimates of attentional capacity that are directly comparable to estimates from human studies.

AB - RationaleThe 5-choice serial reaction time task (5-CSRTT) is widely used to measure rodent attentional functions. In humans, many attention studies in healthy and clinical populations have used testing based on Bundesen’s Theory of Visual Attention (TVA) to estimate visual processing speeds and other parameters of attentional capacity.ObjectivesWe aimed to bridge these research fields by modifying the 5-CSRTT’s design and by mathematically modelling data to derive attentional parameters analogous to human TVA-based measures.MethodsC57BL/6 mice were tested in two 1-h sessions on consecutive days with a version of the 5-CSRTT where stimulus duration (SD) probe length was varied based on information from previous TVA studies. Thereafter, a scopolamine hydrobromide (HBr; 0.125 or 0.25 mg/kg) pharmacological challenge was undertaken, using a Latin square design. Mean score values were modelled using a new three-parameter version of TVA to obtain estimates of visual processing speeds, visual thresholds and motor response baselines in each mouse.ResultsThe parameter estimates for each animal were reliable across sessions, showing that the data were stable enough to support analysis on an individual level. Scopolamine HBr dose-dependently reduced 5-CSRTT attentional performance while also increasing reward collection latency at the highest dose. Upon TVA modelling, scopolamine HBr significantly reduced visual processing speed at both doses, while having less pronounced effects on visual thresholds and motor response baselines.ConclusionsThis study shows for the first time how 5-CSRTT performance in mice can be mathematically modelled to yield estimates of attentional capacity that are directly comparable to estimates from human studies.

KW - Attention

KW - Theory of Visual Attention

KW - 5-choice serial reaction time task

KW - Mouse behaviour

KW - Attention deficit/hyperactivity disorder

KW - Touchscreen operant chamber

KW - Translatable animal models

U2 - 10.1007/s00213-016-4520-6

DO - 10.1007/s00213-016-4520-6

M3 - Journal article

C2 - 28070619

VL - 234

SP - 845

EP - 855

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 5

ER -

ID: 182545067