TY - JOUR

T1 - The therapeutic potential of MicroRNAs in cancer

AU - Thorsen, Stine Buch

AU - Obad, Susanna

AU - Jensen, Niels Frank

AU - Stenvang, Jan

AU - Kauppinen, Sakari

PY - 2012

Y1 - 2012

N2 - MicroRNAs (miRNAs) have been uncovered as important posttranscriptional regulators of nearly every biological process in the cell. Furthermore, mounting evidence implies that miRNAs play key roles in the pathogenesis of cancer and that many miRNAs can function either as oncogenes or tumor suppressors. Thus, miRNAs have rapidly emerged as promising targets for the development of novel anticancer therapeutics. The development of miRNA-based cancer therapeutics relies on restoring the activity of tumor suppressor miRNAs using double-stranded miRNA mimics or inhibition of oncogenic miRNAs using single-stranded antisense oligonucleotides, termed antimiRs. In the present review, we focus on recent advancements in the discovery and development of miRNA-based cancer therapeutics using these 2 approaches. In addition, we summarize selected studies, in which modulation of miRNA activity in preclinical cancer models in vivo has demonstrated promising therapeutic potential.

AB - MicroRNAs (miRNAs) have been uncovered as important posttranscriptional regulators of nearly every biological process in the cell. Furthermore, mounting evidence implies that miRNAs play key roles in the pathogenesis of cancer and that many miRNAs can function either as oncogenes or tumor suppressors. Thus, miRNAs have rapidly emerged as promising targets for the development of novel anticancer therapeutics. The development of miRNA-based cancer therapeutics relies on restoring the activity of tumor suppressor miRNAs using double-stranded miRNA mimics or inhibition of oncogenic miRNAs using single-stranded antisense oligonucleotides, termed antimiRs. In the present review, we focus on recent advancements in the discovery and development of miRNA-based cancer therapeutics using these 2 approaches. In addition, we summarize selected studies, in which modulation of miRNA activity in preclinical cancer models in vivo has demonstrated promising therapeutic potential.

KW - Animals

KW - Antineoplastic Agents

KW - Gene Expression Regulation, Neoplastic

KW - Genes, Tumor Suppressor

KW - Humans

KW - MicroRNAs

KW - Molecular Mimicry

KW - Molecular Targeted Therapy

KW - Neoplasms

KW - Oligonucleotides, Antisense

KW - Oncogenes

KW - miRNA

KW - cancer

KW - therapeutics

KW - oncomir

KW - oncogene

KW - tumor suppressor

KW - antimiR

KW - mimic

U2 - 10.1097/PPO.0b013e318258b5d6

DO - 10.1097/PPO.0b013e318258b5d6

M3 - Journal article

C2 - 22647365

VL - 18

SP - 275

EP - 284

JO - Cancer Journal

JF - Cancer Journal

SN - 1528-9117

IS - 3

ER -