The role of skin barrier in occupational contact dermatitis
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The role of skin barrier in occupational contact dermatitis. / Jakasa, Ivone; Thyssen, Jacob P.; Kezic, Sanja.
In: Experimental Dermatology, Vol. 27, No. 8, 2018, p. 909-914.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The role of skin barrier in occupational contact dermatitis
AU - Jakasa, Ivone
AU - Thyssen, Jacob P.
AU - Kezic, Sanja
PY - 2018
Y1 - 2018
N2 - Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occupational skin diseases, especially in occupations associated with frequent skin contact with irritants and contact allergens. Although ICD and ACD have similar clinical manifestation, their pathophysiology and the role of the skin barrier are different. In ICD, perturbation of the skin barrier is the primary event which sets into motion diverse metabolic processes and triggers activation of innate immunity without the involvement of adaptive immune system. In ACD, a type IV hypersensitivity reaction induced by contact allergens, the skin barrier impairment may evoke innate signalling pathways during the sensitization phase required for the activation of T-cell adaptive response. Thus, skin barrier impairment may increase the risk of ICD or ACD not only because of enhanced permeability and ingress of irritants and allergens but also by the generation of innate immune signal needed for the induction of allergic response. Hence, an efficient way to prevent CD is to avoid skin barrier damage in the workplace. This review focuses on the skin barrier, how it is affected by skin irritants and how its impairment contributes to the development of ICD and ACD.
AB - Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occupational skin diseases, especially in occupations associated with frequent skin contact with irritants and contact allergens. Although ICD and ACD have similar clinical manifestation, their pathophysiology and the role of the skin barrier are different. In ICD, perturbation of the skin barrier is the primary event which sets into motion diverse metabolic processes and triggers activation of innate immunity without the involvement of adaptive immune system. In ACD, a type IV hypersensitivity reaction induced by contact allergens, the skin barrier impairment may evoke innate signalling pathways during the sensitization phase required for the activation of T-cell adaptive response. Thus, skin barrier impairment may increase the risk of ICD or ACD not only because of enhanced permeability and ingress of irritants and allergens but also by the generation of innate immune signal needed for the induction of allergic response. Hence, an efficient way to prevent CD is to avoid skin barrier damage in the workplace. This review focuses on the skin barrier, how it is affected by skin irritants and how its impairment contributes to the development of ICD and ACD.
KW - allergic contact dermatitis
KW - innate immunity
KW - irritant contact dermatitis
KW - occupational skin diseases
KW - review
KW - stratum corneum
U2 - 10.1111/exd.13704
DO - 10.1111/exd.13704
M3 - Review
C2 - 29894020
AN - SCOPUS:85052525685
VL - 27
SP - 909
EP - 914
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 8
ER -
ID: 218517180