The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial

Research output: Contribution to journalJournal articlepeer-review

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The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans : A Randomized, Controlled Trial. / Teysseire, Fabienne; Bordier, Valentine; Budzinska, Aleksandra; Weltens, Nathalie; Rehfeld, Jens F; Holst, Jens J; Hartmann, Bolette; Beglinger, Christoph; Van Oudenhove, Lukas; Wölnerhanssen, Bettina K; Meyer-Gerspach, Anne Christin.

In: Journal of Nutrition, Vol. 152, No. 5, 2022, p. 1228–1238,.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Teysseire, F, Bordier, V, Budzinska, A, Weltens, N, Rehfeld, JF, Holst, JJ, Hartmann, B, Beglinger, C, Van Oudenhove, L, Wölnerhanssen, BK & Meyer-Gerspach, AC 2022, 'The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial', Journal of Nutrition, vol. 152, no. 5, pp. 1228–1238,. https://doi.org/10.1093/jn/nxac026

APA

Teysseire, F., Bordier, V., Budzinska, A., Weltens, N., Rehfeld, J. F., Holst, J. J., Hartmann, B., Beglinger, C., Van Oudenhove, L., Wölnerhanssen, B. K., & Meyer-Gerspach, A. C. (2022). The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial. Journal of Nutrition, 152(5), 1228–1238,. https://doi.org/10.1093/jn/nxac026

Vancouver

Teysseire F, Bordier V, Budzinska A, Weltens N, Rehfeld JF, Holst JJ et al. The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial. Journal of Nutrition. 2022;152(5):1228–1238,. https://doi.org/10.1093/jn/nxac026

Author

Teysseire, Fabienne ; Bordier, Valentine ; Budzinska, Aleksandra ; Weltens, Nathalie ; Rehfeld, Jens F ; Holst, Jens J ; Hartmann, Bolette ; Beglinger, Christoph ; Van Oudenhove, Lukas ; Wölnerhanssen, Bettina K ; Meyer-Gerspach, Anne Christin. / The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans : A Randomized, Controlled Trial. In: Journal of Nutrition. 2022 ; Vol. 152, No. 5. pp. 1228–1238,.

Bibtex

@article{7359445cccc149d9ae390df00892592d,
title = "The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial",
abstract = "BACKGROUND: Glucose induces the release of gastrointestinal (GI) satiation hormones, such as glucagon-like peptide-1 (GLP-1), and peptide tyrosine tyrosine (PYY) in part via the activation of the gut sweet taste receptor (T1R2/T1R3).OBJECTIVES: The primary objective was to investigate the importance of T1R2/T1R3 for the release of cholecystokinin (CCK), GLP-1 and PYY in response to D-allulose and erythritol by assessing the effect of the T1R2/T1R3 antagonist lactisole on these responses and as secondary objectives to study the effect of the T1R2/T1R3 blockade on gastric emptying, appetite-related sensations and GI symptoms.METHODS: In this randomized, controlled, double-blind, cross-over study, 18 participants (five men, mean ± SD BMI: 21.9 ± 1.7 kg/m2, age: 24 ± 4 y) received an intragastric administration of 25 g D-allulose, 50 g erythritol, or tap water, with or without 450 parts per million (ppm) lactisole, respectively, in six different sessions. 13C-sodium acetate was added to all solutions to determine gastric emptying. At fixed time intervals, blood and breath samples were collected, and appetite-related sensations and GI symptoms were assessed. Data were analyzed with linear mixed model analysis.RESULTS: D-allulose and erythritol induced a significant release of CCK, GLP-1 and PYY compared to tap water (all PHolm < 0.0001, dz > 1). Lactisole did not affect the D-allulose- and erythritol-induced release of CCK, GLP-1, and PYY (all PHolm > 0.1). Erythritol significantly delayed gastric emptying, increased fullness and decreased prospective food consumption compared to tap water (PHolm = 0.0002, dz = -1.05, PHolm = 0.0190, dz = 0.69 and PHolm = 0.0442, dz = -0.62, respectively).CONCLUSIONS: D-allulose and erythritol stimulate the secretion of GI satiation hormones in humans. Lactisole had no effect on CCK, GLP-1, and PYY release, indicating that D-allulose- and erythritol-induced GI satiation hormone release is not mediated via T1R2/T1R3 in the gut. Clinical Trial Registry number and website: Number: NCT04027283, Website: https://clinicaltrials.gov/ct2/show/NCT04027283?term=NCT04027283&draw=2&rank=1.",
author = "Fabienne Teysseire and Valentine Bordier and Aleksandra Budzinska and Nathalie Weltens and Rehfeld, {Jens F} and Holst, {Jens J} and Bolette Hartmann and Christoph Beglinger and {Van Oudenhove}, Lukas and W{\"o}lnerhanssen, {Bettina K} and Meyer-Gerspach, {Anne Christin}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.",
year = "2022",
doi = "10.1093/jn/nxac026",
language = "English",
volume = "152",
pages = "1228–1238,",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "5",

}

RIS

TY - JOUR

T1 - The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans

T2 - A Randomized, Controlled Trial

AU - Teysseire, Fabienne

AU - Bordier, Valentine

AU - Budzinska, Aleksandra

AU - Weltens, Nathalie

AU - Rehfeld, Jens F

AU - Holst, Jens J

AU - Hartmann, Bolette

AU - Beglinger, Christoph

AU - Van Oudenhove, Lukas

AU - Wölnerhanssen, Bettina K

AU - Meyer-Gerspach, Anne Christin

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Glucose induces the release of gastrointestinal (GI) satiation hormones, such as glucagon-like peptide-1 (GLP-1), and peptide tyrosine tyrosine (PYY) in part via the activation of the gut sweet taste receptor (T1R2/T1R3).OBJECTIVES: The primary objective was to investigate the importance of T1R2/T1R3 for the release of cholecystokinin (CCK), GLP-1 and PYY in response to D-allulose and erythritol by assessing the effect of the T1R2/T1R3 antagonist lactisole on these responses and as secondary objectives to study the effect of the T1R2/T1R3 blockade on gastric emptying, appetite-related sensations and GI symptoms.METHODS: In this randomized, controlled, double-blind, cross-over study, 18 participants (five men, mean ± SD BMI: 21.9 ± 1.7 kg/m2, age: 24 ± 4 y) received an intragastric administration of 25 g D-allulose, 50 g erythritol, or tap water, with or without 450 parts per million (ppm) lactisole, respectively, in six different sessions. 13C-sodium acetate was added to all solutions to determine gastric emptying. At fixed time intervals, blood and breath samples were collected, and appetite-related sensations and GI symptoms were assessed. Data were analyzed with linear mixed model analysis.RESULTS: D-allulose and erythritol induced a significant release of CCK, GLP-1 and PYY compared to tap water (all PHolm < 0.0001, dz > 1). Lactisole did not affect the D-allulose- and erythritol-induced release of CCK, GLP-1, and PYY (all PHolm > 0.1). Erythritol significantly delayed gastric emptying, increased fullness and decreased prospective food consumption compared to tap water (PHolm = 0.0002, dz = -1.05, PHolm = 0.0190, dz = 0.69 and PHolm = 0.0442, dz = -0.62, respectively).CONCLUSIONS: D-allulose and erythritol stimulate the secretion of GI satiation hormones in humans. Lactisole had no effect on CCK, GLP-1, and PYY release, indicating that D-allulose- and erythritol-induced GI satiation hormone release is not mediated via T1R2/T1R3 in the gut. Clinical Trial Registry number and website: Number: NCT04027283, Website: https://clinicaltrials.gov/ct2/show/NCT04027283?term=NCT04027283&draw=2&rank=1.

AB - BACKGROUND: Glucose induces the release of gastrointestinal (GI) satiation hormones, such as glucagon-like peptide-1 (GLP-1), and peptide tyrosine tyrosine (PYY) in part via the activation of the gut sweet taste receptor (T1R2/T1R3).OBJECTIVES: The primary objective was to investigate the importance of T1R2/T1R3 for the release of cholecystokinin (CCK), GLP-1 and PYY in response to D-allulose and erythritol by assessing the effect of the T1R2/T1R3 antagonist lactisole on these responses and as secondary objectives to study the effect of the T1R2/T1R3 blockade on gastric emptying, appetite-related sensations and GI symptoms.METHODS: In this randomized, controlled, double-blind, cross-over study, 18 participants (five men, mean ± SD BMI: 21.9 ± 1.7 kg/m2, age: 24 ± 4 y) received an intragastric administration of 25 g D-allulose, 50 g erythritol, or tap water, with or without 450 parts per million (ppm) lactisole, respectively, in six different sessions. 13C-sodium acetate was added to all solutions to determine gastric emptying. At fixed time intervals, blood and breath samples were collected, and appetite-related sensations and GI symptoms were assessed. Data were analyzed with linear mixed model analysis.RESULTS: D-allulose and erythritol induced a significant release of CCK, GLP-1 and PYY compared to tap water (all PHolm < 0.0001, dz > 1). Lactisole did not affect the D-allulose- and erythritol-induced release of CCK, GLP-1, and PYY (all PHolm > 0.1). Erythritol significantly delayed gastric emptying, increased fullness and decreased prospective food consumption compared to tap water (PHolm = 0.0002, dz = -1.05, PHolm = 0.0190, dz = 0.69 and PHolm = 0.0442, dz = -0.62, respectively).CONCLUSIONS: D-allulose and erythritol stimulate the secretion of GI satiation hormones in humans. Lactisole had no effect on CCK, GLP-1, and PYY release, indicating that D-allulose- and erythritol-induced GI satiation hormone release is not mediated via T1R2/T1R3 in the gut. Clinical Trial Registry number and website: Number: NCT04027283, Website: https://clinicaltrials.gov/ct2/show/NCT04027283?term=NCT04027283&draw=2&rank=1.

U2 - 10.1093/jn/nxac026

DO - 10.1093/jn/nxac026

M3 - Journal article

C2 - 35135006

VL - 152

SP - 1228–1238,

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 5

ER -

ID: 292141360