The role of AMPKΥ3 in skeletal muscle: Glucose metabolism, Insulin action and AMPK activity

Research output: Book/ReportPh.D. thesis

  • Nicolas Oldenburg Eskesen
During exercise molecular signaling within the muscle cell is initiated. AMP-activated protein kinase (AMPK) senses changes in the cell’s energy level. It has been suggested that AMPK initiates molecular signaling that is beneficial for metabolic health of muscles. AMPK is found in many forms, but the present thesis focuses on AMPKγ3 that is very responsive to exercise and is only found in skeletal muscle.

Through exercise-like interventions in mice and studies of both human and mouse carriers of AMPKγ3 mutations, the role of AMPKγ3 for the regulation of glucose metabolism, insulin action and AMPK activation was investigated.

It was demonstrated that AMPKγ3 is dispensable for pharmacological regulation of glucose uptake in muscle but necessary for the regulation of insulin sensitivity in the period after muscle contractions. Furthermore, it was found that mutations in certain parts of the AMPKγ3 protein affects the activity of the kinase directly.
Original languageEnglish
PublisherDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
Number of pages209
Publication statusPublished - 2022

ID: 322882006