TY - JOUR

T1 - The prognostic impact of incidental prostate cancer following radical cystoprostatectomy

T2 - a nationwide analysis

AU - Jønck, Simon

AU - Thomas Helgstrand, John

AU - Andreas Røder, Martin

AU - Klemann, Nina

AU - Grønkaer Toft, Birgitte

AU - Brasso, Klaus

PY - 2018

Y1 - 2018

N2 - Background: To determine the prevalence and prognostic impact of incidental prostate cancer in patients undergoing radical cystoprostatectomy. Methods: A nationwide population-based study of incidental prostate cancer diagnosed following radical cystoprostatectomy. Information on vital status, Gleason score, positive and negative tumor margins, pT-category and subsequent prostate cancer therapies were obtained from the Danish Prostate Cancer Registry and by manual chart review. Results: A total of 1,450 men who underwent radical cystoprostatectomy in Denmark from 1995–2011 were identified. Forty-six men were excluded from analysis, thus 1,404 patients were eligible. The median follow-up was 7.8 years. A total of 466 (33.2%) had incidental prostate cancer diagnosed. No statistical differences in 10- and 15-year cumulative overall mortality were observed when comparing men with, or without, incidental prostate cancer. In men diagnosed with incidental prostate cancer, neither Gleason score, positive surgical margins or locally advanced prostate cancer (pT3–4) was associated with mortality. Only 0.9% received post-operative prostate cancer-related treatment. Conclusion: In this population-based cohort of patients with incidental prostate cancer diagnosed at radical cystoprostatectomy, we found no impact of incidental prostate cancer on overall mortality, regardless of Gleason score, surgical margin status and pathological T-category. Patients diagnosed with incidental prostate cancer following radical cystoprostatectomy are unlikely to benefit from additional follow-up.

AB - Background: To determine the prevalence and prognostic impact of incidental prostate cancer in patients undergoing radical cystoprostatectomy. Methods: A nationwide population-based study of incidental prostate cancer diagnosed following radical cystoprostatectomy. Information on vital status, Gleason score, positive and negative tumor margins, pT-category and subsequent prostate cancer therapies were obtained from the Danish Prostate Cancer Registry and by manual chart review. Results: A total of 1,450 men who underwent radical cystoprostatectomy in Denmark from 1995–2011 were identified. Forty-six men were excluded from analysis, thus 1,404 patients were eligible. The median follow-up was 7.8 years. A total of 466 (33.2%) had incidental prostate cancer diagnosed. No statistical differences in 10- and 15-year cumulative overall mortality were observed when comparing men with, or without, incidental prostate cancer. In men diagnosed with incidental prostate cancer, neither Gleason score, positive surgical margins or locally advanced prostate cancer (pT3–4) was associated with mortality. Only 0.9% received post-operative prostate cancer-related treatment. Conclusion: In this population-based cohort of patients with incidental prostate cancer diagnosed at radical cystoprostatectomy, we found no impact of incidental prostate cancer on overall mortality, regardless of Gleason score, surgical margin status and pathological T-category. Patients diagnosed with incidental prostate cancer following radical cystoprostatectomy are unlikely to benefit from additional follow-up.

KW - Gleason score

KW - incidental prostate cancer

KW - mortality

KW - multicenter

KW - nationwide

KW - radical cystoprostatectomy

U2 - 10.1080/21681805.2018.1534885

DO - 10.1080/21681805.2018.1534885

M3 - Journal article

C2 - 30624125

AN - SCOPUS:85060244981

VL - 52

SP - 358

EP - 363

JO - Scandinavian Journal of Urology

JF - Scandinavian Journal of Urology

SN - 2168-1805

IS - 5-6

ER -