The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

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The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.
Original languageEnglish
JournalParasitology International
Issue number4
Pages (from-to)478-80
Number of pages2
Publication statusPublished - 2009

ID: 17055131