The personality trait openness is related to cerebral 5-HTT levels

Research output: Contribution to journalJournal articlepeer-review

Standard

The personality trait openness is related to cerebral 5-HTT levels. / Kalbitzer, Jan; Frokjaer, Vibe G; Erritzoe, David; Svarer, Claus; Cumming, Paul; Nielsen, Finn A; Hashemi, Sayed H; Baaré, William F C; Madsen, Jacob; Hasselbalch, Steen G; Kringelbach, Morten L; Mortensen, Erik Lykke; Knudsen, Gitte M.

In: NeuroImage, Vol. 45, No. 2, 2009, p. 280-5.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kalbitzer, J, Frokjaer, VG, Erritzoe, D, Svarer, C, Cumming, P, Nielsen, FA, Hashemi, SH, Baaré, WFC, Madsen, J, Hasselbalch, SG, Kringelbach, ML, Mortensen, EL & Knudsen, GM 2009, 'The personality trait openness is related to cerebral 5-HTT levels', NeuroImage, vol. 45, no. 2, pp. 280-5. https://doi.org/10.1016/j.neuroimage.2008.12.001

APA

Kalbitzer, J., Frokjaer, V. G., Erritzoe, D., Svarer, C., Cumming, P., Nielsen, F. A., Hashemi, S. H., Baaré, W. F. C., Madsen, J., Hasselbalch, S. G., Kringelbach, M. L., Mortensen, E. L., & Knudsen, G. M. (2009). The personality trait openness is related to cerebral 5-HTT levels. NeuroImage, 45(2), 280-5. https://doi.org/10.1016/j.neuroimage.2008.12.001

Vancouver

Kalbitzer J, Frokjaer VG, Erritzoe D, Svarer C, Cumming P, Nielsen FA et al. The personality trait openness is related to cerebral 5-HTT levels. NeuroImage. 2009;45(2):280-5. https://doi.org/10.1016/j.neuroimage.2008.12.001

Author

Kalbitzer, Jan ; Frokjaer, Vibe G ; Erritzoe, David ; Svarer, Claus ; Cumming, Paul ; Nielsen, Finn A ; Hashemi, Sayed H ; Baaré, William F C ; Madsen, Jacob ; Hasselbalch, Steen G ; Kringelbach, Morten L ; Mortensen, Erik Lykke ; Knudsen, Gitte M. / The personality trait openness is related to cerebral 5-HTT levels. In: NeuroImage. 2009 ; Vol. 45, No. 2. pp. 280-5.

Bibtex

@article{c9a4a1401f8311de9f0a000ea68e967b,
title = "The personality trait openness is related to cerebral 5-HTT levels",
abstract = "Potentiation of serotonergic transmission increases cognitive flexibility, but can in other circumstances increase sensitivity to stressful environmental cues. The personality trait Openness to Experience reflects and is also associated with an increased risk for mood disorders. We hypothesized that the personality trait has an association with a biomarker of serotonergic transmission, the plasma membrane serotonin transporter (5-HTT). In 50 healthy volunteers, we tested for correlations between scores on the NEO-PI-R scale Openness to Experience and its subscales, and cerebral binding of the 5-HTT selective PET radioligand [11C]DASB. Subjects were genotyped for the 5-HTT long/short polymorphism, and for a single nucleotide polymorphism in the long allele, designated LA/LG. Midbrain [11C]DASB binding correlated negatively with scores for Openness to Experience and its two subscales, Openness to Actions and Openness to Values. The latter subscore was negatively correlated with [11C]DASB binding in all brain regions in which [11C]DASB binding was quantified. Genetic analysis showed that homozygote LA carriers had significantly higher [11C]DASB binding in the caudate nucleus, but no significant differences in openness scores. Thus, high scores in personality facets indicative of cognitive flexibility and openness to change are associated with lower [11C]DASB binding. Lower abundance of 5-HTT sites may result in potentiation of serotonergic signaling, which occurs during treatment with SSRIs. We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress.",
author = "Jan Kalbitzer and Frokjaer, {Vibe G} and David Erritzoe and Claus Svarer and Paul Cumming and Nielsen, {Finn A} and Hashemi, {Sayed H} and Baar{\'e}, {William F C} and Jacob Madsen and Hasselbalch, {Steen G} and Kringelbach, {Morten L} and Mortensen, {Erik Lykke} and Knudsen, {Gitte M}",
year = "2009",
doi = "10.1016/j.neuroimage.2008.12.001",
language = "English",
volume = "45",
pages = "280--5",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - The personality trait openness is related to cerebral 5-HTT levels

AU - Kalbitzer, Jan

AU - Frokjaer, Vibe G

AU - Erritzoe, David

AU - Svarer, Claus

AU - Cumming, Paul

AU - Nielsen, Finn A

AU - Hashemi, Sayed H

AU - Baaré, William F C

AU - Madsen, Jacob

AU - Hasselbalch, Steen G

AU - Kringelbach, Morten L

AU - Mortensen, Erik Lykke

AU - Knudsen, Gitte M

PY - 2009

Y1 - 2009

N2 - Potentiation of serotonergic transmission increases cognitive flexibility, but can in other circumstances increase sensitivity to stressful environmental cues. The personality trait Openness to Experience reflects and is also associated with an increased risk for mood disorders. We hypothesized that the personality trait has an association with a biomarker of serotonergic transmission, the plasma membrane serotonin transporter (5-HTT). In 50 healthy volunteers, we tested for correlations between scores on the NEO-PI-R scale Openness to Experience and its subscales, and cerebral binding of the 5-HTT selective PET radioligand [11C]DASB. Subjects were genotyped for the 5-HTT long/short polymorphism, and for a single nucleotide polymorphism in the long allele, designated LA/LG. Midbrain [11C]DASB binding correlated negatively with scores for Openness to Experience and its two subscales, Openness to Actions and Openness to Values. The latter subscore was negatively correlated with [11C]DASB binding in all brain regions in which [11C]DASB binding was quantified. Genetic analysis showed that homozygote LA carriers had significantly higher [11C]DASB binding in the caudate nucleus, but no significant differences in openness scores. Thus, high scores in personality facets indicative of cognitive flexibility and openness to change are associated with lower [11C]DASB binding. Lower abundance of 5-HTT sites may result in potentiation of serotonergic signaling, which occurs during treatment with SSRIs. We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress.

AB - Potentiation of serotonergic transmission increases cognitive flexibility, but can in other circumstances increase sensitivity to stressful environmental cues. The personality trait Openness to Experience reflects and is also associated with an increased risk for mood disorders. We hypothesized that the personality trait has an association with a biomarker of serotonergic transmission, the plasma membrane serotonin transporter (5-HTT). In 50 healthy volunteers, we tested for correlations between scores on the NEO-PI-R scale Openness to Experience and its subscales, and cerebral binding of the 5-HTT selective PET radioligand [11C]DASB. Subjects were genotyped for the 5-HTT long/short polymorphism, and for a single nucleotide polymorphism in the long allele, designated LA/LG. Midbrain [11C]DASB binding correlated negatively with scores for Openness to Experience and its two subscales, Openness to Actions and Openness to Values. The latter subscore was negatively correlated with [11C]DASB binding in all brain regions in which [11C]DASB binding was quantified. Genetic analysis showed that homozygote LA carriers had significantly higher [11C]DASB binding in the caudate nucleus, but no significant differences in openness scores. Thus, high scores in personality facets indicative of cognitive flexibility and openness to change are associated with lower [11C]DASB binding. Lower abundance of 5-HTT sites may result in potentiation of serotonergic signaling, which occurs during treatment with SSRIs. We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress.

U2 - 10.1016/j.neuroimage.2008.12.001

DO - 10.1016/j.neuroimage.2008.12.001

M3 - Journal article

C2 - 19135154

VL - 45

SP - 280

EP - 285

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 2

ER -

ID: 11711534