The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine
Final published version, 1.35 MB, PDF document
BACKGROUND: To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.
DISCUSSION: KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.
CONCLUSION: We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.
Original language | English |
---|---|
Article number | 90 |
Journal | Journal of Headache and Pain |
Volume | 18 |
Number of pages | 9 |
ISSN | 1129-2369 |
DOIs | |
Publication status | Published - 23 Aug 2017 |
- Journal Article
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 185366795