The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition. / Li, Xuanji; Stokholm, Jakob; Brejnrod, Asker; Vestergaard, Gisle Alberg; Russel, Jakob; Trivedi, Urvish; Thorsen, Jonathan; Gupta, Shashank; Hjelmsø, Mathis Hjort; Shah, Shiraz A.; Rasmussen, Morten Arendt; Bisgaard, Hans; Sørensen, Søren Johannes.

In: Cell Host & Microbe, Vol. 29, No. 6, 2021, p. 975–987.e4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, X, Stokholm, J, Brejnrod, A, Vestergaard, GA, Russel, J, Trivedi, U, Thorsen, J, Gupta, S, Hjelmsø, MH, Shah, SA, Rasmussen, MA, Bisgaard, H & Sørensen, SJ 2021, 'The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition', Cell Host & Microbe, vol. 29, no. 6, pp. 975–987.e4. https://doi.org/10.1016/j.chom.2021.03.017

APA

Li, X., Stokholm, J., Brejnrod, A., Vestergaard, G. A., Russel, J., Trivedi, U., Thorsen, J., Gupta, S., Hjelmsø, M. H., Shah, S. A., Rasmussen, M. A., Bisgaard, H., & Sørensen, S. J. (2021). The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition. Cell Host & Microbe, 29(6), 975–987.e4. https://doi.org/10.1016/j.chom.2021.03.017

Vancouver

Li X, Stokholm J, Brejnrod A, Vestergaard GA, Russel J, Trivedi U et al. The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition. Cell Host & Microbe. 2021;29(6):975–987.e4. https://doi.org/10.1016/j.chom.2021.03.017

Author

Li, Xuanji ; Stokholm, Jakob ; Brejnrod, Asker ; Vestergaard, Gisle Alberg ; Russel, Jakob ; Trivedi, Urvish ; Thorsen, Jonathan ; Gupta, Shashank ; Hjelmsø, Mathis Hjort ; Shah, Shiraz A. ; Rasmussen, Morten Arendt ; Bisgaard, Hans ; Sørensen, Søren Johannes. / The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition. In: Cell Host & Microbe. 2021 ; Vol. 29, No. 6. pp. 975–987.e4.

Bibtex

@article{1279198732ff433e8e751a26f344d120,

title = "The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition",

abstract = "Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is acquired during early life remain largely unknown. In a cohort of 662 Danish children, we characterized the antibiotic resistance genes (ARGs) acquired during the first year of life and assessed the impacts of diverse environmental exposures on ARG load. Our study reveals a clear bimodal distribution of ARG richness that is driven by the composition of the gut microbiome, especially E. coli. ARG profiles were significantly affected by various environmental factors. Among these factors, the importance of antibiotics diminished with time since treatment. Finally, ARG load and ARG clusters were also associated with the maturity of the gut microbiome and a bacterial composition associated with increased risk of asthma. These findings broaden our understanding of AMR in early life and have critical implications for efforts to mitigate its spread.",

author = "Xuanji Li and Jakob Stokholm and Asker Brejnrod and Vestergaard, {Gisle Alberg} and Jakob Russel and Urvish Trivedi and Jonathan Thorsen and Shashank Gupta and Hjelms{\o}, {Mathis Hjort} and Shah, {Shiraz A.} and Rasmussen, {Morten Arendt} and Hans Bisgaard and S{\o}rensen, {S{\o}ren Johannes}",

year = "2021",

doi = "10.1016/j.chom.2021.03.017",

language = "English",

volume = "29",

pages = "975–987.e4",

journal = "Cell Host & Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "6",

}

RIS

TY - JOUR

T1 - The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition

AU - Li, Xuanji

AU - Stokholm, Jakob

AU - Brejnrod, Asker

AU - Vestergaard, Gisle Alberg

AU - Russel, Jakob

AU - Trivedi, Urvish

AU - Thorsen, Jonathan

AU - Gupta, Shashank

AU - Hjelmsø, Mathis Hjort

AU - Shah, Shiraz A.

AU - Rasmussen, Morten Arendt

AU - Bisgaard, Hans

AU - Sørensen, Søren Johannes

PY - 2021

Y1 - 2021

N2 - Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is acquired during early life remain largely unknown. In a cohort of 662 Danish children, we characterized the antibiotic resistance genes (ARGs) acquired during the first year of life and assessed the impacts of diverse environmental exposures on ARG load. Our study reveals a clear bimodal distribution of ARG richness that is driven by the composition of the gut microbiome, especially E. coli. ARG profiles were significantly affected by various environmental factors. Among these factors, the importance of antibiotics diminished with time since treatment. Finally, ARG load and ARG clusters were also associated with the maturity of the gut microbiome and a bacterial composition associated with increased risk of asthma. These findings broaden our understanding of AMR in early life and have critical implications for efforts to mitigate its spread.

AB - Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is acquired during early life remain largely unknown. In a cohort of 662 Danish children, we characterized the antibiotic resistance genes (ARGs) acquired during the first year of life and assessed the impacts of diverse environmental exposures on ARG load. Our study reveals a clear bimodal distribution of ARG richness that is driven by the composition of the gut microbiome, especially E. coli. ARG profiles were significantly affected by various environmental factors. Among these factors, the importance of antibiotics diminished with time since treatment. Finally, ARG load and ARG clusters were also associated with the maturity of the gut microbiome and a bacterial composition associated with increased risk of asthma. These findings broaden our understanding of AMR in early life and have critical implications for efforts to mitigate its spread.

U2 - 10.1016/j.chom.2021.03.017

DO - 10.1016/j.chom.2021.03.017

M3 - Journal article

C2 - 33887206

VL - 29

SP - 975–987.e4

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 6

ER -

ID: 260542334