The implication of Pseudomonas aeruginosa biofilms in infections
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The implication of Pseudomonas aeruginosa biofilms in infections. / Rybtke, Morten T; Jensen, Peter Østrup; Høiby, Niels; Givskov, Michael; Tolker-Nielsen, Tim; Bjarnsholt, Thomas.
In: Inflammation & Allergy - Drug Targets, Vol. 10, No. 2, 2011, p. 141-57.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - The implication of Pseudomonas aeruginosa biofilms in infections
AU - Rybtke, Morten T
AU - Jensen, Peter Østrup
AU - Høiby, Niels
AU - Givskov, Michael
AU - Tolker-Nielsen, Tim
AU - Bjarnsholt, Thomas
PY - 2011
Y1 - 2011
N2 - Biofilm formation by bacteria is recognized as a major problem in chronic infections due to their recalcitrance against the immune defense and available antibiotic treatment schemes. The opportunistic pathogen Pseudomonas aeruginosa has drawn special attention in this regard due to its severity of infection in the lungs of cystic fibrosis patients and in chronic wounds. In this review we address the molecular basis of biofilm development by P. aeruginosa as well as the mechanisms employed by this bacterium in the increased tolerance displayed against antimicrobials. The complex build-up of the extracellular matrix encasing the biofilm-associated bacteria as well as the elaborate signaling mechanisms employed by the bacterium enables it to withstand the continuous stresses imposed by the immune defense and administered antibiotics resulting in a state of chronic inflammation that damages the host. The immune response leading to this chronic inflammation is described. Finally, novel treatment strategies against P. aeruginosa are described including, quorum-sensing inhibition and induced biofilm-dispersion. The tolerance towards currently available antimicrobials calls for development of alternative treatment strategies where the underlying targets are less prone for resistance development as bacteria, in retrospect, have a unique ability to evade the actions of classic antibiotics.
AB - Biofilm formation by bacteria is recognized as a major problem in chronic infections due to their recalcitrance against the immune defense and available antibiotic treatment schemes. The opportunistic pathogen Pseudomonas aeruginosa has drawn special attention in this regard due to its severity of infection in the lungs of cystic fibrosis patients and in chronic wounds. In this review we address the molecular basis of biofilm development by P. aeruginosa as well as the mechanisms employed by this bacterium in the increased tolerance displayed against antimicrobials. The complex build-up of the extracellular matrix encasing the biofilm-associated bacteria as well as the elaborate signaling mechanisms employed by the bacterium enables it to withstand the continuous stresses imposed by the immune defense and administered antibiotics resulting in a state of chronic inflammation that damages the host. The immune response leading to this chronic inflammation is described. Finally, novel treatment strategies against P. aeruginosa are described including, quorum-sensing inhibition and induced biofilm-dispersion. The tolerance towards currently available antimicrobials calls for development of alternative treatment strategies where the underlying targets are less prone for resistance development as bacteria, in retrospect, have a unique ability to evade the actions of classic antibiotics.
KW - Animals
KW - Anti-Bacterial Agents
KW - Biofilms
KW - Drug Delivery Systems
KW - Drug Resistance, Bacterial
KW - Humans
KW - Inflammation
KW - Pseudomonas Infections
KW - Pseudomonas aeruginosa
M3 - Journal article
C2 - 21314623
VL - 10
SP - 141
EP - 157
JO - Inflammation and Allergy - Drug Targets
JF - Inflammation and Allergy - Drug Targets
SN - 1871-5281
IS - 2
ER -
ID: 44311232