The implication of Pseudomonas aeruginosa biofilms in infections

Research output: Contribution to journalJournal articlepeer-review

Standard

The implication of Pseudomonas aeruginosa biofilms in infections. / Rybtke, Morten T; Jensen, Peter Østrup; Høiby, Niels; Givskov, Michael; Tolker-Nielsen, Tim; Bjarnsholt, Thomas.

In: Inflammation & Allergy - Drug Targets, Vol. 10, No. 2, 2011, p. 141-57.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rybtke, MT, Jensen, PØ, Høiby, N, Givskov, M, Tolker-Nielsen, T & Bjarnsholt, T 2011, 'The implication of Pseudomonas aeruginosa biofilms in infections', Inflammation & Allergy - Drug Targets, vol. 10, no. 2, pp. 141-57.

APA

Rybtke, M. T., Jensen, P. Ø., Høiby, N., Givskov, M., Tolker-Nielsen, T., & Bjarnsholt, T. (2011). The implication of Pseudomonas aeruginosa biofilms in infections. Inflammation & Allergy - Drug Targets, 10(2), 141-57.

Vancouver

Rybtke MT, Jensen PØ, Høiby N, Givskov M, Tolker-Nielsen T, Bjarnsholt T. The implication of Pseudomonas aeruginosa biofilms in infections. Inflammation & Allergy - Drug Targets. 2011;10(2):141-57.

Author

Rybtke, Morten T ; Jensen, Peter Østrup ; Høiby, Niels ; Givskov, Michael ; Tolker-Nielsen, Tim ; Bjarnsholt, Thomas. / The implication of Pseudomonas aeruginosa biofilms in infections. In: Inflammation & Allergy - Drug Targets. 2011 ; Vol. 10, No. 2. pp. 141-57.

Bibtex

@article{8354349610bc4b8cb6766e8b62b73f64,
title = "The implication of Pseudomonas aeruginosa biofilms in infections",
abstract = "Biofilm formation by bacteria is recognized as a major problem in chronic infections due to their recalcitrance against the immune defense and available antibiotic treatment schemes. The opportunistic pathogen Pseudomonas aeruginosa has drawn special attention in this regard due to its severity of infection in the lungs of cystic fibrosis patients and in chronic wounds. In this review we address the molecular basis of biofilm development by P. aeruginosa as well as the mechanisms employed by this bacterium in the increased tolerance displayed against antimicrobials. The complex build-up of the extracellular matrix encasing the biofilm-associated bacteria as well as the elaborate signaling mechanisms employed by the bacterium enables it to withstand the continuous stresses imposed by the immune defense and administered antibiotics resulting in a state of chronic inflammation that damages the host. The immune response leading to this chronic inflammation is described. Finally, novel treatment strategies against P. aeruginosa are described including, quorum-sensing inhibition and induced biofilm-dispersion. The tolerance towards currently available antimicrobials calls for development of alternative treatment strategies where the underlying targets are less prone for resistance development as bacteria, in retrospect, have a unique ability to evade the actions of classic antibiotics.",
keywords = "Animals, Anti-Bacterial Agents, Biofilms, Drug Delivery Systems, Drug Resistance, Bacterial, Humans, Inflammation, Pseudomonas Infections, Pseudomonas aeruginosa",
author = "Rybtke, {Morten T} and Jensen, {Peter {\O}strup} and Niels H{\o}iby and Michael Givskov and Tim Tolker-Nielsen and Thomas Bjarnsholt",
year = "2011",
language = "English",
volume = "10",
pages = "141--57",
journal = "Inflammation and Allergy - Drug Targets",
issn = "1871-5281",
publisher = "Bentham Science Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - The implication of Pseudomonas aeruginosa biofilms in infections

AU - Rybtke, Morten T

AU - Jensen, Peter Østrup

AU - Høiby, Niels

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

AU - Bjarnsholt, Thomas

PY - 2011

Y1 - 2011

N2 - Biofilm formation by bacteria is recognized as a major problem in chronic infections due to their recalcitrance against the immune defense and available antibiotic treatment schemes. The opportunistic pathogen Pseudomonas aeruginosa has drawn special attention in this regard due to its severity of infection in the lungs of cystic fibrosis patients and in chronic wounds. In this review we address the molecular basis of biofilm development by P. aeruginosa as well as the mechanisms employed by this bacterium in the increased tolerance displayed against antimicrobials. The complex build-up of the extracellular matrix encasing the biofilm-associated bacteria as well as the elaborate signaling mechanisms employed by the bacterium enables it to withstand the continuous stresses imposed by the immune defense and administered antibiotics resulting in a state of chronic inflammation that damages the host. The immune response leading to this chronic inflammation is described. Finally, novel treatment strategies against P. aeruginosa are described including, quorum-sensing inhibition and induced biofilm-dispersion. The tolerance towards currently available antimicrobials calls for development of alternative treatment strategies where the underlying targets are less prone for resistance development as bacteria, in retrospect, have a unique ability to evade the actions of classic antibiotics.

AB - Biofilm formation by bacteria is recognized as a major problem in chronic infections due to their recalcitrance against the immune defense and available antibiotic treatment schemes. The opportunistic pathogen Pseudomonas aeruginosa has drawn special attention in this regard due to its severity of infection in the lungs of cystic fibrosis patients and in chronic wounds. In this review we address the molecular basis of biofilm development by P. aeruginosa as well as the mechanisms employed by this bacterium in the increased tolerance displayed against antimicrobials. The complex build-up of the extracellular matrix encasing the biofilm-associated bacteria as well as the elaborate signaling mechanisms employed by the bacterium enables it to withstand the continuous stresses imposed by the immune defense and administered antibiotics resulting in a state of chronic inflammation that damages the host. The immune response leading to this chronic inflammation is described. Finally, novel treatment strategies against P. aeruginosa are described including, quorum-sensing inhibition and induced biofilm-dispersion. The tolerance towards currently available antimicrobials calls for development of alternative treatment strategies where the underlying targets are less prone for resistance development as bacteria, in retrospect, have a unique ability to evade the actions of classic antibiotics.

KW - Animals

KW - Anti-Bacterial Agents

KW - Biofilms

KW - Drug Delivery Systems

KW - Drug Resistance, Bacterial

KW - Humans

KW - Inflammation

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

M3 - Journal article

C2 - 21314623

VL - 10

SP - 141

EP - 157

JO - Inflammation and Allergy - Drug Targets

JF - Inflammation and Allergy - Drug Targets

SN - 1871-5281

IS - 2

ER -

ID: 44311232