The impact of the postnatal gut microbiota on animal models
Research output: Contribution to journal › Conference article › peer-review
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The impact of the postnatal gut microbiota on animal models. / Hansen, Axel Jacob Kornerup; Ejsing-Duun, Maria; Aasted, Bent; Josephsen, Jytte; Christensen, Gitte Bach; Dahl, Kirsten; Vogensen, Finn Kvist; Hufeldt, Majbritt Ravn; Buschard, Karsten Stig.
In: Laboratory Animals. Journal of the Laboratory Animal Science Association, 2007, p. 95-99.Research output: Contribution to journal › Conference article › peer-review
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TY - GEN
T1 - The impact of the postnatal gut microbiota on animal models
AU - Hansen, Axel Jacob Kornerup
AU - Ejsing-Duun, Maria
AU - Aasted, Bent
AU - Josephsen, Jytte
AU - Christensen, Gitte Bach
AU - Dahl, Kirsten
AU - Vogensen, Finn Kvist
AU - Hufeldt, Majbritt Ravn
AU - Buschard, Karsten Stig
N1 - Conference code: 10
PY - 2007
Y1 - 2007
N2 - Quality control of laboratory animals has been mostly concentrated on eliminating and securing the absence of specific infections, but event barrier bred laboratory animals harbour a huge number of gut bacteria. There is scientific evidence that the nature of the gut microbiota especially in early life - has an impact on the maturation of the immune system and thereby on the development of inflammatory deseases. In several studies, the prevalence of diseases such as rheumatic arthititis (RA), allergies, inflammatory bowel disease (IBD) an type 1 diabetes (T1D) has been shown to be positively correlated to factors related to early exposure to microorganisms, e.g. the so-called hygiene hypothesis claims that the increasing human incidence of allergy. T1D, RA and IBD may be due to the lack of such exposure. It is possible today by various molecular techniques to profile the gut microbiota of a laboratory animal, and such techniques should be applied to document uniform animals from laboratory animal vendors to secure standardization and thereby lower variation and smaller group sizes.
AB - Quality control of laboratory animals has been mostly concentrated on eliminating and securing the absence of specific infections, but event barrier bred laboratory animals harbour a huge number of gut bacteria. There is scientific evidence that the nature of the gut microbiota especially in early life - has an impact on the maturation of the immune system and thereby on the development of inflammatory deseases. In several studies, the prevalence of diseases such as rheumatic arthititis (RA), allergies, inflammatory bowel disease (IBD) an type 1 diabetes (T1D) has been shown to be positively correlated to factors related to early exposure to microorganisms, e.g. the so-called hygiene hypothesis claims that the increasing human incidence of allergy. T1D, RA and IBD may be due to the lack of such exposure. It is possible today by various molecular techniques to profile the gut microbiota of a laboratory animal, and such techniques should be applied to document uniform animals from laboratory animal vendors to secure standardization and thereby lower variation and smaller group sizes.
M3 - Conference article
SP - 95
EP - 99
JO - Laboratory Animals
JF - Laboratory Animals
SN - 0023-6772
Y2 - 11 June 2007 through 14 June 2007
ER -
ID: 15864733