The impact of comorbidity on mortality in multiple myeloma: a Danish nationwide population-based study

Research output: Contribution to journalJournal articleResearchpeer-review

  • Henrik Gregersen
  • Vangsted, Annette Juul
  • Niels Abildgaard
  • Niels Frost Andersen
  • Robert Schou Pedersen
  • Ulf Christian Frølund
  • Carsten Helleberg
  • Bettina Broch
  • Per Trøllund Pedersen
  • Peter Gimsing
  • Tobias Wirenfeldt Klausen

To describe the prevalence of comorbidity and its impact on survival in newly diagnosed multiple myeloma patients compared with population controls. Cases of newly diagnosed symptomatic multiple myeloma during the 2005-2012 period were identified in the Danish National Multiple Myeloma Registry. For each myeloma patient, 10 members of the general population matched by age and sex were chosen from the national Civil Registration System. Data on comorbidity in the myeloma patients and the general population comparison cohort were collected by linkage to the Danish National Patient Registry (DNPR). Cox proportional hazards regression models were used to evaluate the prognostic significance of comorbidity. The study included 2190 cases of multiple myeloma and 21,900 population controls. The comorbidity was increased in multiple myeloma patients compared with population controls, odds ratio (OR) 1.4 (1.1-1.7). The registration of comorbidity was highly increased within the year preceding diagnosis of multiple myeloma (OR 3.0 [2.5-3.5]), which was attributable to an increased registration of various diseases, in particular, renal disease with OR 11.0 (8.1-14.9). The median follow-up time from diagnosis of multiple myeloma for patients alive was 4.3 years (interquartile range 2.4-6.3). Patients with registered comorbidity had increased mortality compared with patients without comorbidity, hazard ratio 1.6 (1.5-1.8). Multiple myeloma patients have increased comorbidity compared with the background population, in particular during the year preceding the diagnosis of myeloma.

Original languageEnglish
JournalCancer Medicine
Issue number7
Pages (from-to)1807-1816
Number of pages10
Publication statusPublished - Jun 2017

    Research areas

  • Adult, Aged, Aged, 80 and over, Case-Control Studies, Comorbidity, Denmark/epidemiology, Female, Hematopoietic Stem Cell Transplantation, Humans, Male, Melphalan/administration & dosage, Middle Aged, Mortality, Multiple Myeloma/diagnosis, Odds Ratio, Population Surveillance, Prognosis, Proportional Hazards Models, Registries, Risk Factors, Transplantation Conditioning, Young Adult

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