The human milk microbiota is modulated by maternal diet
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The human milk microbiota is modulated by maternal diet. / Padilha, Marina; Danneskiold-Samsøe, Niels Banhos; Brejnrod, Asker; Hoffmann, Christian; Cabral, Vanessa Pereira; Iaucci, Julia de Melo; Sales, Cristiane Hermes; Fisberg, Regina Mara; Cortez, Ramon Vitor; Brix, Susanne; Taddei, Carla Romano; Kristiansen, Karsten; Saad, Susana Marta Isay.
In: Microorganisms, Vol. 7, No. 11, 502, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The human milk microbiota is modulated by maternal diet
AU - Padilha, Marina
AU - Danneskiold-Samsøe, Niels Banhos
AU - Brejnrod, Asker
AU - Hoffmann, Christian
AU - Cabral, Vanessa Pereira
AU - Iaucci, Julia de Melo
AU - Sales, Cristiane Hermes
AU - Fisberg, Regina Mara
AU - Cortez, Ramon Vitor
AU - Brix, Susanne
AU - Taddei, Carla Romano
AU - Kristiansen, Karsten
AU - Saad, Susana Marta Isay
PY - 2019
Y1 - 2019
N2 - Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota.
AB - Human milk microorganisms contribute not only to the healthy development of the immune system in infants, but also in shaping the gut microbiota. We evaluated the effect of the maternal diet during pregnancy and during the first month of lactation on the human milk microbiota in a cross-sectional study including 94 healthy lactating women. Microbiota composition was determined by 16S rDNA profiling and nutrient intake assessed through food questionnaires. Thirteen genera were present in at least 90% of all samples, with three genera present in all samples: Streptococcus, Staphylococcus, and Corynebacterium. Cluster analysis indicated two distinct compositions: one marked by a high abundance of Streptococcus (cluster 1), and other by a high abundance of Staphylococcus (cluster 2). A global association with milk microbiota diversity was observed for vitamin C intake during pregnancy (p = 0.029), which was higher for cluster 2 individuals (cluster 2 median = 232 mg/d; cluster 1 = 175 mg/d; p = 0.02). Positive correlations were found between Bifidobacterium in the milk and intake of polyunsaturated and linoleic fatty acids during the lactation period (p < 0.01). We show that maternal diet influences the human milk microbiota, especially during pregnancy, which may contribute in shaping the gut microbiota.
KW - Breast milk
KW - Breastfeeding
KW - Gut colonization
KW - Maternal diet
KW - Microbiota
U2 - 10.3390/microorganisms7110502
DO - 10.3390/microorganisms7110502
M3 - Journal article
C2 - 31671720
AN - SCOPUS:85074386132
VL - 7
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
IS - 11
M1 - 502
ER -
ID: 230095726