The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation
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The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation. / Lund, Kit P.; Eriksson, Frank; Hauge, Anne W.; Mora-Jensen, Helena I.; Sørensen, Søren S.; Bruunsgaard, Helle.
In: Clinical Immunology, Vol. 226, 108711, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The HLA-DR4-DQ8 phenotype of the recipient is associated with increased mortality after kidney transplantation
AU - Lund, Kit P.
AU - Eriksson, Frank
AU - Hauge, Anne W.
AU - Mora-Jensen, Helena I.
AU - Sørensen, Søren S.
AU - Bruunsgaard, Helle
PY - 2021
Y1 - 2021
N2 - The importance of the human leukocyte antigen (HLA) system in kidney transplantation is well-known, but it remains unexplored if patient HLA antigens constitute independent risk factors in complications after transplantation. We hypothesized that specific HLA class II phenotypes associated with immune-mediated disease (HLA-IMD) predispose to immunological activity and/or complications after kidney transplantation. Based on the literature we defined HLA-DR2-DQ6; -DR3-DQ2 and -DR4-DQ8 as HLA-IMD phenotypes. We investigated associations between HLA-IMD phenotypes in patients, biomarkers of systemic chronic inflammation at the time of transplantation, and the outcome after kidney transplantation in a retrospective cohort study of 611 kidney transplanted patients. The HLA-IMD phenotypes were associated with higher levels of biomarkers of systemic inflammation. The HLA-DR4-DQ8 phenotype was associated with mortality after transplantation in Cox analyses with adjustments for confounders. Data support the hypothesis that specific HLA class II phenotypes affects immunological pathways that determine the midterm clinical outcome of kidney transplantation.
AB - The importance of the human leukocyte antigen (HLA) system in kidney transplantation is well-known, but it remains unexplored if patient HLA antigens constitute independent risk factors in complications after transplantation. We hypothesized that specific HLA class II phenotypes associated with immune-mediated disease (HLA-IMD) predispose to immunological activity and/or complications after kidney transplantation. Based on the literature we defined HLA-DR2-DQ6; -DR3-DQ2 and -DR4-DQ8 as HLA-IMD phenotypes. We investigated associations between HLA-IMD phenotypes in patients, biomarkers of systemic chronic inflammation at the time of transplantation, and the outcome after kidney transplantation in a retrospective cohort study of 611 kidney transplanted patients. The HLA-IMD phenotypes were associated with higher levels of biomarkers of systemic inflammation. The HLA-DR4-DQ8 phenotype was associated with mortality after transplantation in Cox analyses with adjustments for confounders. Data support the hypothesis that specific HLA class II phenotypes affects immunological pathways that determine the midterm clinical outcome of kidney transplantation.
KW - HLA
KW - Inflammation
KW - Kidney transplantation
KW - Mortality
U2 - 10.1016/j.clim.2021.108711
DO - 10.1016/j.clim.2021.108711
M3 - Journal article
C2 - 33667637
AN - SCOPUS:85102463723
VL - 226
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
M1 - 108711
ER -
ID: 259045804