The genetics of obesity: from discovery to biology
Research output: Contribution to journal › Review › Research › peer-review
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.
Original language | English |
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Journal | Nature Reviews Genetics |
Volume | 23 |
Pages (from-to) | 120-133 |
ISSN | 1471-0056 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Publisher Copyright:
© 2021, Springer Nature Limited.
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459824/pdf/41576_2021_Article_414.pdf
Final published version
ID: 281163638