The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans: A Randomized Controlled Trial
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The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans : A Randomized Controlled Trial. / Bressendorff, Iain; Brandi, Lisbet; Schou, Morten; Nygaard, Birgitte Ulsøe; Frandsen, Niels Erik; Rasmussen, Knud; Ødum, Lars; Oestergaard, Ove Vyff; Hansen, Ditte.
In: PLoS ONE, Vol. 11, No. 8, e0160905, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans
T2 - A Randomized Controlled Trial
AU - Bressendorff, Iain
AU - Brandi, Lisbet
AU - Schou, Morten
AU - Nygaard, Birgitte Ulsøe
AU - Frandsen, Niels Erik
AU - Rasmussen, Knud
AU - Ødum, Lars
AU - Oestergaard, Ove Vyff
AU - Hansen, Ditte
PY - 2016
Y1 - 2016
N2 - BACKGROUND: Low levels of serum 25-hydroxy vitamin D are associated with increased arterial stiffness and hypertension. Supplementation with vitamin D precursors has been proposed as a treatment option for these conditions. We examined the effect of oral cholecalciferol on arterial stiffness and blood pressure in healthy normotensive adults.METHODS: 40 healthy adults were randomised in this double-blinded study to either oral cholecalciferol 3000 IU/day or matching placebo and were followed for 16 weeks to examine any effects on pulse wave velocity (PWV), augmentation index (AIx), peripheral and central blood pressure and 24-hour ambulatory blood pressure.RESULTS: 22 subjects in the cholecalciferol arm and 18 subjects in the placebo arm completed the 16 weeks of follow-up. There was no difference in changes in PWV, AIx corrected for heart rate or central or peripheral blood pressure between the two groups. There was no correlation between serum 25-hydroxy vitamin D and any of these parameters.CONCLUSIONS: Oral cholecalciferol 3000 IU/day does not affect arterial stiffness or blood pressure after 16 weeks of treatment in healthy normotensive adults.TRIAL REGISTRATION: ClinicalTrials.gov NCT00952562.
AB - BACKGROUND: Low levels of serum 25-hydroxy vitamin D are associated with increased arterial stiffness and hypertension. Supplementation with vitamin D precursors has been proposed as a treatment option for these conditions. We examined the effect of oral cholecalciferol on arterial stiffness and blood pressure in healthy normotensive adults.METHODS: 40 healthy adults were randomised in this double-blinded study to either oral cholecalciferol 3000 IU/day or matching placebo and were followed for 16 weeks to examine any effects on pulse wave velocity (PWV), augmentation index (AIx), peripheral and central blood pressure and 24-hour ambulatory blood pressure.RESULTS: 22 subjects in the cholecalciferol arm and 18 subjects in the placebo arm completed the 16 weeks of follow-up. There was no difference in changes in PWV, AIx corrected for heart rate or central or peripheral blood pressure between the two groups. There was no correlation between serum 25-hydroxy vitamin D and any of these parameters.CONCLUSIONS: Oral cholecalciferol 3000 IU/day does not affect arterial stiffness or blood pressure after 16 weeks of treatment in healthy normotensive adults.TRIAL REGISTRATION: ClinicalTrials.gov NCT00952562.
U2 - 10.1371/journal.pone.0160905
DO - 10.1371/journal.pone.0160905
M3 - Journal article
C2 - 27509187
VL - 11
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 8
M1 - e0160905
ER -
ID: 177437143