The discovery of bacterial biofilm in patients with muscle invasive bladder cancer

Research output: Contribution to journalJournal articlepeer-review

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The discovery of bacterial biofilm in patients with muscle invasive bladder cancer. / Nadler, Naomi; Kvich, Lasse; Bjarnsholt, Thomas; Jensen, Jorgen Bjerggaard; Gogenur, Ismail; Azawi, Nessn.

In: APMIS, Vol. 129, No. 5, 2021, p. 265-270.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Nadler, N, Kvich, L, Bjarnsholt, T, Jensen, JB, Gogenur, I & Azawi, N 2021, 'The discovery of bacterial biofilm in patients with muscle invasive bladder cancer', APMIS, vol. 129, no. 5, pp. 265-270. https://doi.org/10.1111/apm.13097

APA

Nadler, N., Kvich, L., Bjarnsholt, T., Jensen, J. B., Gogenur, I., & Azawi, N. (2021). The discovery of bacterial biofilm in patients with muscle invasive bladder cancer. APMIS, 129(5), 265-270. https://doi.org/10.1111/apm.13097

Vancouver

Nadler N, Kvich L, Bjarnsholt T, Jensen JB, Gogenur I, Azawi N. The discovery of bacterial biofilm in patients with muscle invasive bladder cancer. APMIS. 2021;129(5):265-270. https://doi.org/10.1111/apm.13097

Author

Nadler, Naomi ; Kvich, Lasse ; Bjarnsholt, Thomas ; Jensen, Jorgen Bjerggaard ; Gogenur, Ismail ; Azawi, Nessn. / The discovery of bacterial biofilm in patients with muscle invasive bladder cancer. In: APMIS. 2021 ; Vol. 129, No. 5. pp. 265-270.

Bibtex

@article{df54a381ba9949d59dbb5a88a278b807,
title = "The discovery of bacterial biofilm in patients with muscle invasive bladder cancer",
abstract = "The carcinogenic effects of microorganisms have been discovered in multiple cancer types. In urology, the development of squamous cell carcinoma of the bladder due to the parasitic infection with Schistosoma Mansoni is widely accepted. The oncogenic potential of biofilms has been studied in colorectal cancer and experimental studies have shown that bacteria such as Escherichia coli drive the development of colorectal cancer. Notably, Escherichia coli is responsible for 80% of all urinary tract infections. Recent findings suggest an altered urinary microbiome in patients with bladder cancer compared to healthy subjects. In this case series, we demonstrate our findings of biofilm formation in human bladder cancer tissue. Tissue samples from ten patients that underwent routine Transurethral Resection of Bladder Tumor (TURBT) were obtained from the Danish National Biobank. Pathological tissue was examined for presence of bacterial aggregates by Fluorescence in situ Hybridization. In two of ten patients, analysis showed abundant bacterial aggregation on the surface epithelium. Both positive cases had pT2 urothelial bladder cancer. Our findings suggest that biofilm occurs in urothelial cancer tissue indicating an association between biofilm formation and bladder cancer.",
keywords = "Bladder cancer, microbiome, translational science",
author = "Naomi Nadler and Lasse Kvich and Thomas Bjarnsholt and Jensen, {Jorgen Bjerggaard} and Ismail Gogenur and Nessn Azawi",
year = "2021",
doi = "10.1111/apm.13097",
language = "English",
volume = "129",
pages = "265--270",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "5",

}

RIS

TY - JOUR

T1 - The discovery of bacterial biofilm in patients with muscle invasive bladder cancer

AU - Nadler, Naomi

AU - Kvich, Lasse

AU - Bjarnsholt, Thomas

AU - Jensen, Jorgen Bjerggaard

AU - Gogenur, Ismail

AU - Azawi, Nessn

PY - 2021

Y1 - 2021

N2 - The carcinogenic effects of microorganisms have been discovered in multiple cancer types. In urology, the development of squamous cell carcinoma of the bladder due to the parasitic infection with Schistosoma Mansoni is widely accepted. The oncogenic potential of biofilms has been studied in colorectal cancer and experimental studies have shown that bacteria such as Escherichia coli drive the development of colorectal cancer. Notably, Escherichia coli is responsible for 80% of all urinary tract infections. Recent findings suggest an altered urinary microbiome in patients with bladder cancer compared to healthy subjects. In this case series, we demonstrate our findings of biofilm formation in human bladder cancer tissue. Tissue samples from ten patients that underwent routine Transurethral Resection of Bladder Tumor (TURBT) were obtained from the Danish National Biobank. Pathological tissue was examined for presence of bacterial aggregates by Fluorescence in situ Hybridization. In two of ten patients, analysis showed abundant bacterial aggregation on the surface epithelium. Both positive cases had pT2 urothelial bladder cancer. Our findings suggest that biofilm occurs in urothelial cancer tissue indicating an association between biofilm formation and bladder cancer.

AB - The carcinogenic effects of microorganisms have been discovered in multiple cancer types. In urology, the development of squamous cell carcinoma of the bladder due to the parasitic infection with Schistosoma Mansoni is widely accepted. The oncogenic potential of biofilms has been studied in colorectal cancer and experimental studies have shown that bacteria such as Escherichia coli drive the development of colorectal cancer. Notably, Escherichia coli is responsible for 80% of all urinary tract infections. Recent findings suggest an altered urinary microbiome in patients with bladder cancer compared to healthy subjects. In this case series, we demonstrate our findings of biofilm formation in human bladder cancer tissue. Tissue samples from ten patients that underwent routine Transurethral Resection of Bladder Tumor (TURBT) were obtained from the Danish National Biobank. Pathological tissue was examined for presence of bacterial aggregates by Fluorescence in situ Hybridization. In two of ten patients, analysis showed abundant bacterial aggregation on the surface epithelium. Both positive cases had pT2 urothelial bladder cancer. Our findings suggest that biofilm occurs in urothelial cancer tissue indicating an association between biofilm formation and bladder cancer.

KW - Bladder cancer

KW - microbiome

KW - translational science

U2 - 10.1111/apm.13097

DO - 10.1111/apm.13097

M3 - Journal article

C2 - 33205550

VL - 129

SP - 265

EP - 270

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 5

ER -

ID: 259623412