The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence

Research output: Contribution to journalJournal articlepeer-review

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The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence. / Spedden, Meaghan Elizabeth; Jensen, Peter; Terkildsen, Cecilie Ulbæk; Jensen, Nicole Jacqueline; Halliday, David M; Lundbye-Jensen, Jesper; Nielsen, Jens Bo; Geertsen, Svend Sparre.

In: NeuroImage, Vol. 191, 2019, p. 350-360.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Spedden, ME, Jensen, P, Terkildsen, CU, Jensen, NJ, Halliday, DM, Lundbye-Jensen, J, Nielsen, JB & Geertsen, SS 2019, 'The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence', NeuroImage, vol. 191, pp. 350-360. https://doi.org/10.1016/j.neuroimage.2019.02.054

APA

Spedden, M. E., Jensen, P., Terkildsen, C. U., Jensen, N. J., Halliday, D. M., Lundbye-Jensen, J., Nielsen, J. B., & Geertsen, S. S. (2019). The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence. NeuroImage, 191, 350-360. https://doi.org/10.1016/j.neuroimage.2019.02.054

Vancouver

Spedden ME, Jensen P, Terkildsen CU, Jensen NJ, Halliday DM, Lundbye-Jensen J et al. The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence. NeuroImage. 2019;191:350-360. https://doi.org/10.1016/j.neuroimage.2019.02.054

Author

Spedden, Meaghan Elizabeth ; Jensen, Peter ; Terkildsen, Cecilie Ulbæk ; Jensen, Nicole Jacqueline ; Halliday, David M ; Lundbye-Jensen, Jesper ; Nielsen, Jens Bo ; Geertsen, Svend Sparre. / The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence. In: NeuroImage. 2019 ; Vol. 191. pp. 350-360.

Bibtex

@article{e837d0e6ad784c1593071633df3d71da,
title = "The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence",
abstract = "In adults, oscillatory activity in the sensorimotor cortex is coherent with contralateral muscle activity at beta frequencies (15-35 Hz) during tonic contraction. This functional coupling reflects the involvement of the sensorimotor cortex, the corticospinal pathway, and likely also ascending sensory feedback in the task at hand. However, little is known about the developmental trajectory of task-related corticomuscular connectivity relating to the voluntary control of the ankle muscles. To address this, we recorded electroencephalography (EEG) from the vertex (Cz) and electromyography (EMG) from ankle muscles (proximal and distal anterior tibial, TA; soleus, SOL; gastrocnemius medialis, GM) in 33 participants aged 7-23 yr during tonic dorsi- and plantar flexion requiring precise maintenance of a submaximal torque level. Coherence was calculated for Cz-TA, Cz-SOL, TA-TA, and SOL-GM signal pairs. We found strong, positive associations between age and beta band coherence for Cz-TA, Cz-SOL, and TA-TA, suggesting that oscillatory corticomuscular connectivity is strengthened during childhood development and adolescence. Directionality analysis indicated that the primary interaction underlying this age-related increase was in the descending direction. In addition, performance during dorsi- and plantar flexion tasks was positively associated with age, indicating more precise control of the ankle joint in older participants. Performance was also positively associated with beta band coherence, suggesting that participants with greater coherence also exhibited greater precision. We propose that these results indicate an age-related increase in oscillatory corticospinal input to the ankle muscle motoneuron pools during childhood development and adolescence, with possible implications for maturation of precision force control. Within the theoretical framework of predictive coding, we suggest that our results may reflect an age-related increase in reliance on feedforward control as the developing nervous system becomes better at predicting the sensory consequences of movement. These findings may contribute to the development of novel intervention strategies targeting improved sensorimotor control in children and adolescents with central motor disorders.",
keywords = "Faculty of Science, Coherence, EEG, EMG, Development, Connectivity",
author = "Spedden, {Meaghan Elizabeth} and Peter Jensen and Terkildsen, {Cecilie Ulb{\ae}k} and Jensen, {Nicole Jacqueline} and Halliday, {David M} and Jesper Lundbye-Jensen and Nielsen, {Jens Bo} and Geertsen, {Svend Sparre}",
note = "CURIS 2019 NEXS 081 Copyright {\textcopyright} 2019. Published by Elsevier Inc.",
year = "2019",
doi = "10.1016/j.neuroimage.2019.02.054",
language = "English",
volume = "191",
pages = "350--360",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The development of functional and directed corticomuscular connectivity during tonic ankle muscle contraction across childhood and adolescence

AU - Spedden, Meaghan Elizabeth

AU - Jensen, Peter

AU - Terkildsen, Cecilie Ulbæk

AU - Jensen, Nicole Jacqueline

AU - Halliday, David M

AU - Lundbye-Jensen, Jesper

AU - Nielsen, Jens Bo

AU - Geertsen, Svend Sparre

N1 - CURIS 2019 NEXS 081 Copyright © 2019. Published by Elsevier Inc.

PY - 2019

Y1 - 2019

N2 - In adults, oscillatory activity in the sensorimotor cortex is coherent with contralateral muscle activity at beta frequencies (15-35 Hz) during tonic contraction. This functional coupling reflects the involvement of the sensorimotor cortex, the corticospinal pathway, and likely also ascending sensory feedback in the task at hand. However, little is known about the developmental trajectory of task-related corticomuscular connectivity relating to the voluntary control of the ankle muscles. To address this, we recorded electroencephalography (EEG) from the vertex (Cz) and electromyography (EMG) from ankle muscles (proximal and distal anterior tibial, TA; soleus, SOL; gastrocnemius medialis, GM) in 33 participants aged 7-23 yr during tonic dorsi- and plantar flexion requiring precise maintenance of a submaximal torque level. Coherence was calculated for Cz-TA, Cz-SOL, TA-TA, and SOL-GM signal pairs. We found strong, positive associations between age and beta band coherence for Cz-TA, Cz-SOL, and TA-TA, suggesting that oscillatory corticomuscular connectivity is strengthened during childhood development and adolescence. Directionality analysis indicated that the primary interaction underlying this age-related increase was in the descending direction. In addition, performance during dorsi- and plantar flexion tasks was positively associated with age, indicating more precise control of the ankle joint in older participants. Performance was also positively associated with beta band coherence, suggesting that participants with greater coherence also exhibited greater precision. We propose that these results indicate an age-related increase in oscillatory corticospinal input to the ankle muscle motoneuron pools during childhood development and adolescence, with possible implications for maturation of precision force control. Within the theoretical framework of predictive coding, we suggest that our results may reflect an age-related increase in reliance on feedforward control as the developing nervous system becomes better at predicting the sensory consequences of movement. These findings may contribute to the development of novel intervention strategies targeting improved sensorimotor control in children and adolescents with central motor disorders.

AB - In adults, oscillatory activity in the sensorimotor cortex is coherent with contralateral muscle activity at beta frequencies (15-35 Hz) during tonic contraction. This functional coupling reflects the involvement of the sensorimotor cortex, the corticospinal pathway, and likely also ascending sensory feedback in the task at hand. However, little is known about the developmental trajectory of task-related corticomuscular connectivity relating to the voluntary control of the ankle muscles. To address this, we recorded electroencephalography (EEG) from the vertex (Cz) and electromyography (EMG) from ankle muscles (proximal and distal anterior tibial, TA; soleus, SOL; gastrocnemius medialis, GM) in 33 participants aged 7-23 yr during tonic dorsi- and plantar flexion requiring precise maintenance of a submaximal torque level. Coherence was calculated for Cz-TA, Cz-SOL, TA-TA, and SOL-GM signal pairs. We found strong, positive associations between age and beta band coherence for Cz-TA, Cz-SOL, and TA-TA, suggesting that oscillatory corticomuscular connectivity is strengthened during childhood development and adolescence. Directionality analysis indicated that the primary interaction underlying this age-related increase was in the descending direction. In addition, performance during dorsi- and plantar flexion tasks was positively associated with age, indicating more precise control of the ankle joint in older participants. Performance was also positively associated with beta band coherence, suggesting that participants with greater coherence also exhibited greater precision. We propose that these results indicate an age-related increase in oscillatory corticospinal input to the ankle muscle motoneuron pools during childhood development and adolescence, with possible implications for maturation of precision force control. Within the theoretical framework of predictive coding, we suggest that our results may reflect an age-related increase in reliance on feedforward control as the developing nervous system becomes better at predicting the sensory consequences of movement. These findings may contribute to the development of novel intervention strategies targeting improved sensorimotor control in children and adolescents with central motor disorders.

KW - Faculty of Science

KW - Coherence

KW - EEG

KW - EMG

KW - Development

KW - Connectivity

U2 - 10.1016/j.neuroimage.2019.02.054

DO - 10.1016/j.neuroimage.2019.02.054

M3 - Journal article

C2 - 30818025

VL - 191

SP - 350

EP - 360

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

ID: 214299412