The computer as a laboratory for the physical chemistry of membranes
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The computer as a laboratory for the physical chemistry of membranes. / Mouritsen, O. G.; Dammann, B.; Fogedby, H. C.; Ipsen, J. H.; Jeppesen, C.; Jørgensen, K.; Risbo, J.; Sabra, M. C.; Sperotto, M. M.; Zuckermann, M. J.
In: Biophysical Chemistry, Vol. 55, No. 1-2, 1995, p. 55-68.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - The computer as a laboratory for the physical chemistry of membranes
AU - Mouritsen, O. G.
AU - Dammann, B.
AU - Fogedby, H. C.
AU - Ipsen, J. H.
AU - Jeppesen, C.
AU - Jørgensen, K.
AU - Risbo, J.
AU - Sabra, M. C.
AU - Sperotto, M. M.
AU - Zuckermann, M. J.
PY - 1995
Y1 - 1995
N2 - A mini-review is given of some recent advances in the use of computer-simulation approaches to the study of physico-chemical properties of lipid bilayers and biological membranes. The simulations are based on microscopic molecular interaction models as well as random-surface models of fluid membranes. Particular emphasis is put on those properties that are controlled by the many-particle character of the lamellar membrane, i.e. correlations and fluctuations in density, composition and large-scale conformational structure. It is discussed how dynamic membrane heterogeneity arises and how it is affected by various molecular species interacting with membranes, such as cholesterol, drugs, insecticides, as well as polypeptides and integral membrane proteins. The influence of bending rigidity and osmotic-pressure gradients on large-scale membrane conformation and topology is described.
AB - A mini-review is given of some recent advances in the use of computer-simulation approaches to the study of physico-chemical properties of lipid bilayers and biological membranes. The simulations are based on microscopic molecular interaction models as well as random-surface models of fluid membranes. Particular emphasis is put on those properties that are controlled by the many-particle character of the lamellar membrane, i.e. correlations and fluctuations in density, composition and large-scale conformational structure. It is discussed how dynamic membrane heterogeneity arises and how it is affected by various molecular species interacting with membranes, such as cholesterol, drugs, insecticides, as well as polypeptides and integral membrane proteins. The influence of bending rigidity and osmotic-pressure gradients on large-scale membrane conformation and topology is described.
KW - Bending rigidity
KW - Cholesterol
KW - Computer simulation
KW - Dynamic heterogeneity
KW - Fluctuation
KW - Insecticide
KW - Lipid bilayer
KW - Lipid mixture
KW - Lipid-protein interaction
KW - Membrane topology
KW - Phase separation
KW - Phase transition
KW - Random surface
U2 - 10.1016/0301-4622(94)00142-7
DO - 10.1016/0301-4622(94)00142-7
M3 - Journal article
AN - SCOPUS:0029026515
VL - 55
SP - 55
EP - 68
JO - Biophysical Chemistry
JF - Biophysical Chemistry
SN - 0301-4622
IS - 1-2
ER -
ID: 236889021