The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology. / Venning, Freja Albjerg; Claesson, Mogens Helweg; Kissow, Hannelouise.

In: Journal of Cancer Science & Therapy, Vol. 5, No. 11, 2013, p. 377-383.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Venning, FA, Claesson, MH & Kissow, H 2013, 'The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology', Journal of Cancer Science & Therapy, vol. 5, no. 11, pp. 377-383. https://doi.org/10.4172/1948-5956.1000229

APA

Venning, F. A., Claesson, M. H., & Kissow, H. (2013). The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology. Journal of Cancer Science & Therapy, 5(11), 377-383. https://doi.org/10.4172/1948-5956.1000229

Vancouver

Venning FA, Claesson MH, Kissow H. The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology. Journal of Cancer Science & Therapy. 2013;5(11):377-383. https://doi.org/10.4172/1948-5956.1000229

Author

Venning, Freja Albjerg ; Claesson, Mogens Helweg ; Kissow, Hannelouise. / The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology. In: Journal of Cancer Science & Therapy. 2013 ; Vol. 5, No. 11. pp. 377-383.

Bibtex

@article{af068a5cce5d42dfbe9760fad1c3029d,
title = "The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology",
abstract = " Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM by itself did result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.",
keywords = "Faculty of Health and Medical Sciences, Neoplasia, Carcinogenic agent azoxymethane, Histopathology",
author = "Venning, {Freja Albjerg} and Claesson, {Mogens Helweg} and Hannelouise Kissow",
year = "2013",
doi = "10.4172/1948-5956.1000229",
language = "English",
volume = "5",
pages = "377--383",
journal = "Journal of Cancer Science & Therapy",
issn = "1948-5956",
publisher = "OMICS Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

AU - Venning, Freja Albjerg

AU - Claesson, Mogens Helweg

AU - Kissow, Hannelouise

PY - 2013

Y1 - 2013

N2 - Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM by itself did result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.

AB - Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM by itself did result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.

KW - Faculty of Health and Medical Sciences

KW - Neoplasia

KW - Carcinogenic agent azoxymethane

KW - Histopathology

U2 - 10.4172/1948-5956.1000229

DO - 10.4172/1948-5956.1000229

M3 - Journal article

VL - 5

SP - 377

EP - 383

JO - Journal of Cancer Science & Therapy

JF - Journal of Cancer Science & Therapy

SN - 1948-5956

IS - 11

ER -

ID: 91450447