The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression. / Dam, Henrik; Buch, Jens O. D.; Nielsen, Annelaura B.; Weikop, Pia; Jørgensen, Martin B.

In: Translational Neuroscience, Vol. 13, No. 1, 2022, p. 320-326.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dam, H, Buch, JOD, Nielsen, AB, Weikop, P & Jørgensen, MB 2022, 'The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression', Translational Neuroscience, vol. 13, no. 1, pp. 320-326. https://doi.org/10.1515/tnsci-2022-0244

APA

Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, P., & Jørgensen, M. B. (2022). The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression. Translational Neuroscience, 13(1), 320-326. https://doi.org/10.1515/tnsci-2022-0244

Vancouver

Dam H, Buch JOD, Nielsen AB, Weikop P, Jørgensen MB. The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression. Translational Neuroscience. 2022;13(1):320-326. https://doi.org/10.1515/tnsci-2022-0244

Author

Dam, Henrik ; Buch, Jens O. D. ; Nielsen, Annelaura B. ; Weikop, Pia ; Jørgensen, Martin B. / The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression. In: Translational Neuroscience. 2022 ; Vol. 13, No. 1. pp. 320-326.

Bibtex

@article{c4e5fd7935ff4d72950b29bffd997e18,

title = "The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression",

abstract = "Background The CACNA1C protein is a L-type calcium channel, which influence affective disorders. Purpose The purpose of the present study was to examine the possible association between the different genotypes of rs100677 CACNA1C gene and anxiety and other clinical symptoms in patients with unipolar depression. Patients and controls A total of 754 patients and 708 controls from the Danish Psychiatric Biobank participated. Results A significant correlation was found between anxiety and the A allele. It was further found that patients with the A allele more often were treated with electroconvulsive therapy and patients with the AA phenotype had the highest age. Limitations The only information about controls was their sex and that they were recruited from the blood bank. Two types of inclusion criteria were used. The clinical data were not complete for all patients.",

keywords = "CACNA1C, rs1006737, anxiety, depression, ECT, first admission, PERSONALITY-TRAITS, BIPOLAR DISORDER, GENE, VARIANTS, ANK3",

author = "Henrik Dam and Buch, {Jens O. D.} and Nielsen, {Annelaura B.} and Pia Weikop and J{\o}rgensen, {Martin B.}",

year = "2022",

doi = "10.1515/tnsci-2022-0244",

language = "English",

volume = "13",

pages = "320--326",

journal = "Translational Neuroscience",

issn = "2081-3856",

publisher = "De Gruyter Open Ltd.",

number = "1",

}

RIS

TY - JOUR

T1 - The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

AU - Dam, Henrik

AU - Buch, Jens O. D.

AU - Nielsen, Annelaura B.

AU - Weikop, Pia

AU - Jørgensen, Martin B.

PY - 2022

Y1 - 2022

N2 - Background The CACNA1C protein is a L-type calcium channel, which influence affective disorders. Purpose The purpose of the present study was to examine the possible association between the different genotypes of rs100677 CACNA1C gene and anxiety and other clinical symptoms in patients with unipolar depression. Patients and controls A total of 754 patients and 708 controls from the Danish Psychiatric Biobank participated. Results A significant correlation was found between anxiety and the A allele. It was further found that patients with the A allele more often were treated with electroconvulsive therapy and patients with the AA phenotype had the highest age. Limitations The only information about controls was their sex and that they were recruited from the blood bank. Two types of inclusion criteria were used. The clinical data were not complete for all patients.

AB - Background The CACNA1C protein is a L-type calcium channel, which influence affective disorders. Purpose The purpose of the present study was to examine the possible association between the different genotypes of rs100677 CACNA1C gene and anxiety and other clinical symptoms in patients with unipolar depression. Patients and controls A total of 754 patients and 708 controls from the Danish Psychiatric Biobank participated. Results A significant correlation was found between anxiety and the A allele. It was further found that patients with the A allele more often were treated with electroconvulsive therapy and patients with the AA phenotype had the highest age. Limitations The only information about controls was their sex and that they were recruited from the blood bank. Two types of inclusion criteria were used. The clinical data were not complete for all patients.

KW - CACNA1C

KW - rs1006737

KW - anxiety

KW - depression

KW - ECT

KW - first admission

KW - PERSONALITY-TRAITS

KW - BIPOLAR DISORDER

KW - GENE

KW - VARIANTS

KW - ANK3

U2 - 10.1515/tnsci-2022-0244

DO - 10.1515/tnsci-2022-0244

M3 - Journal article

C2 - 36238190

VL - 13

SP - 320

EP - 326

JO - Translational Neuroscience

JF - Translational Neuroscience

SN - 2081-3856

IS - 1

ER -

ID: 321277242