Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement
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Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement. / Sørensen, M B; Fritz-Hansen, T; Jensen, H H; Pedersen, A T; Højgaard, L; Ottesen, B.
In: American Journal of Obstetrics and Gynecology, Vol. 184, No. 2, 01.2001, p. 41-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Temporal changes in cardiac function and cerebral blood flow during sequential postmenopausal hormone replacement
AU - Sørensen, M B
AU - Fritz-Hansen, T
AU - Jensen, H H
AU - Pedersen, A T
AU - Højgaard, L
AU - Ottesen, B
PY - 2001/1
Y1 - 2001/1
N2 - OBJECTIVE: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen.STUDY DESIGN: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times.RESULTS: Systemic vascular resistance was reduced during estradiol (-6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (-5 mm Hg; P =.03) and diastolic (-3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (-37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate.CONCLUSIONS: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow.
AB - OBJECTIVE: The purpose was to assess the temporal changes in cardiac function and cerebral blood flow during postmenopausal administration of estrogen with and without progestogen.STUDY DESIGN: Sixteen postmenopausal volunteers were assessed during estradiol plus sequential norethindrone acetate and placebo in two 12-week periods. Temporal changes were measured by magnetic resonance flow mapping 8 times.RESULTS: Systemic vascular resistance was reduced during estradiol (-6.9%; P <.05), declined further during the addition of norethindrone acetate, and was accompanied by an increase in stroke volume (maximum increase, 5.2%; P <.05) without fluid retention. Both systolic (-5 mm Hg; P =.03) and diastolic (-3 mm Hg; P =.03) blood pressure were reduced during estradiol. Cerebral blood flow was reduced after 9 weeks of hormone replacement therapy (-37 mL/min; P =.01) but increased to baseline after the addition of norethindrone acetate.CONCLUSIONS: Sequential hormone replacement therapy is associated with changes in cardiac function, which are of therapeutic potential in cardiovascular disorders. Sequential hormone replacement therapy exhibits an overall neutral effect on cerebral blood flow.
KW - Blood Pressure
KW - Cardiovascular Diseases
KW - Cerebrovascular Circulation
KW - Cross-Over Studies
KW - Double-Blind Method
KW - Estradiol
KW - Estrogen Replacement Therapy
KW - Female
KW - Heart
KW - Humans
KW - Magnetic Resonance Angiography
KW - Middle Aged
KW - Norethindrone
KW - Placebos
KW - Postmenopause
KW - Stroke Volume
KW - Vascular Resistance
KW - Clinical Trial
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.1067/mob.2001.108333
DO - 10.1067/mob.2001.108333
M3 - Journal article
C2 - 11174477
VL - 184
SP - 41
EP - 47
JO - American Journal of Obstetrics & Gynecology
JF - American Journal of Obstetrics & Gynecology
SN - 0002-9378
IS - 2
ER -
ID: 165883743