Telomere length and depression: prospective cohort study and Mendelian randomisation study in 67 306 individuals
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Telomere length and depression : prospective cohort study and Mendelian randomisation study in 67 306 individuals. / Wium-Andersen, Marie Kim; Ørsted, David Dynnes; Rode, Line; Bojesen, Stig Egil; Nordestgaard, Børge Grønne.
In: The British journal of psychiatry : the journal of mental science, Vol. 210, No. 1, 01.2017, p. 31-38.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Telomere length and depression
T2 - prospective cohort study and Mendelian randomisation study in 67 306 individuals
AU - Wium-Andersen, Marie Kim
AU - Ørsted, David Dynnes
AU - Rode, Line
AU - Bojesen, Stig Egil
AU - Nordestgaard, Børge Grønne
N1 - © The Royal College of Psychiatrists 2017.
PY - 2017/1
Y1 - 2017/1
N2 - BACKGROUND: Depression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear.AIMS: We examined whether short telomere length is associated with depression cross-sectionally as well as prospectively and genetically.METHOD: Telomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67 306 individuals aged 20-100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication.RESULTS: Attendance at hospital for depression was associated with short telomere length cross-sectionally, but not prospectively. Further, purchase of antidepressant medication was not associated with short telomere length cross-sectionally or prospectively. Mean follow-up was 7.6 years (range 0.0-21.5). The genetic analyses suggested that telomere length was not causally associated with attendance at hospital for depression or with purchase of antidepressant medication.CONCLUSIONS: Short telomeres were not associated with depression in prospective or in causal, genetic analyses.
AB - BACKGROUND: Depression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear.AIMS: We examined whether short telomere length is associated with depression cross-sectionally as well as prospectively and genetically.METHOD: Telomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67 306 individuals aged 20-100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication.RESULTS: Attendance at hospital for depression was associated with short telomere length cross-sectionally, but not prospectively. Further, purchase of antidepressant medication was not associated with short telomere length cross-sectionally or prospectively. Mean follow-up was 7.6 years (range 0.0-21.5). The genetic analyses suggested that telomere length was not causally associated with attendance at hospital for depression or with purchase of antidepressant medication.CONCLUSIONS: Short telomeres were not associated with depression in prospective or in causal, genetic analyses.
KW - Journal Article
U2 - 10.1192/bjp.bp.115.178798
DO - 10.1192/bjp.bp.115.178798
M3 - Journal article
C2 - 27810892
VL - 210
SP - 31
EP - 38
JO - The Journal of mental science
JF - The Journal of mental science
SN - 0960-5371
IS - 1
ER -
ID: 178245579