Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. / Thallas-Bonke, Vicki; Coughlan, Melinda T; Tan, Adeline Ly; Harcourt, Brooke E; Morgan, Philip E; Davies, Michael Jonathan; Bach, Leon A; Cooper, Mark E; Forbes, Josephine M.

In: Nephrology, Vol. 18, No. 1, 01.2013, p. 47-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thallas-Bonke, V, Coughlan, MT, Tan, AL, Harcourt, BE, Morgan, PE, Davies, MJ, Bach, LA, Cooper, ME & Forbes, JM 2013, 'Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content', Nephrology, vol. 18, no. 1, pp. 47-56. https://doi.org/10.1111/j.1440-1797.2012.01665.x

APA

Thallas-Bonke, V., Coughlan, M. T., Tan, A. L., Harcourt, B. E., Morgan, P. E., Davies, M. J., Bach, L. A., Cooper, M. E., & Forbes, J. M. (2013). Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. Nephrology, 18(1), 47-56. https://doi.org/10.1111/j.1440-1797.2012.01665.x

Vancouver

Thallas-Bonke V, Coughlan MT, Tan AL, Harcourt BE, Morgan PE, Davies MJ et al. Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. Nephrology. 2013 Jan;18(1):47-56. https://doi.org/10.1111/j.1440-1797.2012.01665.x

Author

Thallas-Bonke, Vicki ; Coughlan, Melinda T ; Tan, Adeline Ly ; Harcourt, Brooke E ; Morgan, Philip E ; Davies, Michael Jonathan ; Bach, Leon A ; Cooper, Mark E ; Forbes, Josephine M. / Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content. In: Nephrology. 2013 ; Vol. 18, No. 1. pp. 47-56.

Bibtex

@article{682f8e6216dd44818158995c4c04eed9,
title = "Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content",
abstract = "AIM: Mouse chow is commonly high in advanced glycation end-products, known contributors to diabetic nephropathy. The aim of this study was to evaluate if targeting of the AGE-RAGE axis was still effective in the context of a diet low in AGE content, which is more comparable to diets consumed by individuals with type 1 diabetes.METHODS: C57BL/6J wild-type and mice deficient in the receptor for AGEs (RAGE-KO) consumed a diet low in AGE content. Groups of mice were given (i) vehicle; (ii) streptozotocin; or (iii) streptozotocin + AGE lowering therapy (alagebrium chloride) and followed for 24 weeks.RESULTS: Diabetic mice had high urinary albumin excretion rates, hyperfiltration and release of urinary Kim-1, not seen in diabetic RAGE-KO mice. Diabetic mice also had renal fibrosis, measured by glomerulosclerosis, tubulointerstitial expansion, TGF-β1 and glomerular collagen-IV deposition which almost all improved by RAGE-KO or alagebium. Diabetic mice had a greater renal burden of AGEs and increased expression of renal specific PKC-α phosphorylation, which was improved in RAGE-KO mice, or those treated with alagebrium.CONCLUSION: Diabetic mice given a low-AGE diet still developed renal disease, which could be attenuated by targeting of the AGE-RAGE axis.",
keywords = "Animals, Diet, Glycosylation End Products, Advanced, Kidney, Male, Mice, Mice, Inbred C57BL, Receptors, Immunologic",
author = "Vicki Thallas-Bonke and Coughlan, {Melinda T} and Tan, {Adeline Ly} and Harcourt, {Brooke E} and Morgan, {Philip E} and Davies, {Michael Jonathan} and Bach, {Leon A} and Cooper, {Mark E} and Forbes, {Josephine M}",
note = "{\textcopyright} 2012 The Authors. Nephrology {\textcopyright} 2012 Asian Pacific Society of Nephrology.",
year = "2013",
month = jan,
doi = "10.1111/j.1440-1797.2012.01665.x",
language = "English",
volume = "18",
pages = "47--56",
journal = "Nephrology",
issn = "1320-5358",
publisher = "Wiley-Blackwell Publishing Asia",
number = "1",

}

RIS

TY - JOUR

T1 - Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

AU - Thallas-Bonke, Vicki

AU - Coughlan, Melinda T

AU - Tan, Adeline Ly

AU - Harcourt, Brooke E

AU - Morgan, Philip E

AU - Davies, Michael Jonathan

AU - Bach, Leon A

AU - Cooper, Mark E

AU - Forbes, Josephine M

N1 - © 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.

PY - 2013/1

Y1 - 2013/1

N2 - AIM: Mouse chow is commonly high in advanced glycation end-products, known contributors to diabetic nephropathy. The aim of this study was to evaluate if targeting of the AGE-RAGE axis was still effective in the context of a diet low in AGE content, which is more comparable to diets consumed by individuals with type 1 diabetes.METHODS: C57BL/6J wild-type and mice deficient in the receptor for AGEs (RAGE-KO) consumed a diet low in AGE content. Groups of mice were given (i) vehicle; (ii) streptozotocin; or (iii) streptozotocin + AGE lowering therapy (alagebrium chloride) and followed for 24 weeks.RESULTS: Diabetic mice had high urinary albumin excretion rates, hyperfiltration and release of urinary Kim-1, not seen in diabetic RAGE-KO mice. Diabetic mice also had renal fibrosis, measured by glomerulosclerosis, tubulointerstitial expansion, TGF-β1 and glomerular collagen-IV deposition which almost all improved by RAGE-KO or alagebium. Diabetic mice had a greater renal burden of AGEs and increased expression of renal specific PKC-α phosphorylation, which was improved in RAGE-KO mice, or those treated with alagebrium.CONCLUSION: Diabetic mice given a low-AGE diet still developed renal disease, which could be attenuated by targeting of the AGE-RAGE axis.

AB - AIM: Mouse chow is commonly high in advanced glycation end-products, known contributors to diabetic nephropathy. The aim of this study was to evaluate if targeting of the AGE-RAGE axis was still effective in the context of a diet low in AGE content, which is more comparable to diets consumed by individuals with type 1 diabetes.METHODS: C57BL/6J wild-type and mice deficient in the receptor for AGEs (RAGE-KO) consumed a diet low in AGE content. Groups of mice were given (i) vehicle; (ii) streptozotocin; or (iii) streptozotocin + AGE lowering therapy (alagebrium chloride) and followed for 24 weeks.RESULTS: Diabetic mice had high urinary albumin excretion rates, hyperfiltration and release of urinary Kim-1, not seen in diabetic RAGE-KO mice. Diabetic mice also had renal fibrosis, measured by glomerulosclerosis, tubulointerstitial expansion, TGF-β1 and glomerular collagen-IV deposition which almost all improved by RAGE-KO or alagebium. Diabetic mice had a greater renal burden of AGEs and increased expression of renal specific PKC-α phosphorylation, which was improved in RAGE-KO mice, or those treated with alagebrium.CONCLUSION: Diabetic mice given a low-AGE diet still developed renal disease, which could be attenuated by targeting of the AGE-RAGE axis.

KW - Animals

KW - Diet

KW - Glycosylation End Products, Advanced

KW - Kidney

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Receptors, Immunologic

U2 - 10.1111/j.1440-1797.2012.01665.x

DO - 10.1111/j.1440-1797.2012.01665.x

M3 - Journal article

C2 - 23046363

VL - 18

SP - 47

EP - 56

JO - Nephrology

JF - Nephrology

SN - 1320-5358

IS - 1

ER -

ID: 128974783