Tablet surface characterisation by various imaging techniques

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Tablet surface characterisation by various imaging techniques. / Seitavuopio, Paulus; Rantanen, Jukka; Yliruusi, Jouko.

In: International Journal of Pharmaceutics, Vol. 254, No. 2, 26.03.2003, p. 281-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Seitavuopio, P, Rantanen, J & Yliruusi, J 2003, 'Tablet surface characterisation by various imaging techniques', International Journal of Pharmaceutics, vol. 254, no. 2, pp. 281-6.

APA

Seitavuopio, P., Rantanen, J., & Yliruusi, J. (2003). Tablet surface characterisation by various imaging techniques. International Journal of Pharmaceutics, 254(2), 281-6.

Vancouver

Seitavuopio P, Rantanen J, Yliruusi J. Tablet surface characterisation by various imaging techniques. International Journal of Pharmaceutics. 2003 Mar 26;254(2):281-6.

Author

Seitavuopio, Paulus ; Rantanen, Jukka ; Yliruusi, Jouko. / Tablet surface characterisation by various imaging techniques. In: International Journal of Pharmaceutics. 2003 ; Vol. 254, No. 2. pp. 281-6.

Bibtex

@article{6340d5eafb804534917c14cf88a4cf36,
title = "Tablet surface characterisation by various imaging techniques",
abstract = "The aim of this study was to characterise tablet surfaces using different imaging and roughness analytical techniques including optical microscopy, scanning electron microscopy (SEM), laser profilometry and atomic force microscopy (AFM). The test materials compressed were potassium chloride (KCl) and sodium chloride (NaCl). It was found that all methods used suggested that the KCl tablets were smoother than the NaCl tablets and higher compression pressure made the tablets smoother. Imaging methods like optical microscopy and SEM can give useful information about the roughness of the sample surface, but they do not provide quantitative information about surface roughness. Laser profilometry and AFM on the other hand provide quantitative roughness data from two different scales, laser profilometer from 1 mm and atomic force microscope from 90 microm scale. AFM is a powerful technique but other imaging and roughness measuring methods like SEM, optical microscopy and laser profilometry give valuable additional information.",
keywords = "Compressive Strength, Lasers, Microscopy, Atomic Force, Microscopy, Electron, Scanning, Particle Size, Potassium Chloride, Sodium Chloride, Surface Properties, Tablets",
author = "Paulus Seitavuopio and Jukka Rantanen and Jouko Yliruusi",
note = "Copyright 2003 Elsevier Science B.V.",
year = "2003",
month = mar,
day = "26",
language = "English",
volume = "254",
pages = "281--6",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Tablet surface characterisation by various imaging techniques

AU - Seitavuopio, Paulus

AU - Rantanen, Jukka

AU - Yliruusi, Jouko

N1 - Copyright 2003 Elsevier Science B.V.

PY - 2003/3/26

Y1 - 2003/3/26

N2 - The aim of this study was to characterise tablet surfaces using different imaging and roughness analytical techniques including optical microscopy, scanning electron microscopy (SEM), laser profilometry and atomic force microscopy (AFM). The test materials compressed were potassium chloride (KCl) and sodium chloride (NaCl). It was found that all methods used suggested that the KCl tablets were smoother than the NaCl tablets and higher compression pressure made the tablets smoother. Imaging methods like optical microscopy and SEM can give useful information about the roughness of the sample surface, but they do not provide quantitative information about surface roughness. Laser profilometry and AFM on the other hand provide quantitative roughness data from two different scales, laser profilometer from 1 mm and atomic force microscope from 90 microm scale. AFM is a powerful technique but other imaging and roughness measuring methods like SEM, optical microscopy and laser profilometry give valuable additional information.

AB - The aim of this study was to characterise tablet surfaces using different imaging and roughness analytical techniques including optical microscopy, scanning electron microscopy (SEM), laser profilometry and atomic force microscopy (AFM). The test materials compressed were potassium chloride (KCl) and sodium chloride (NaCl). It was found that all methods used suggested that the KCl tablets were smoother than the NaCl tablets and higher compression pressure made the tablets smoother. Imaging methods like optical microscopy and SEM can give useful information about the roughness of the sample surface, but they do not provide quantitative information about surface roughness. Laser profilometry and AFM on the other hand provide quantitative roughness data from two different scales, laser profilometer from 1 mm and atomic force microscope from 90 microm scale. AFM is a powerful technique but other imaging and roughness measuring methods like SEM, optical microscopy and laser profilometry give valuable additional information.

KW - Compressive Strength

KW - Lasers

KW - Microscopy, Atomic Force

KW - Microscopy, Electron, Scanning

KW - Particle Size

KW - Potassium Chloride

KW - Sodium Chloride

KW - Surface Properties

KW - Tablets

M3 - Journal article

C2 - 12623204

VL - 254

SP - 281

EP - 286

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 140622923