Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)

Research output: Contribution to journal › Journal article › Research › peer-review

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Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd). / Hrdlicka, Patrick J; Stenvang, Jan; Wengel, Jesper.

In: Nucleosides, nucleotides & nucleic acids, Vol. 24, No. 5-7, 2005, p. 397-400.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hrdlicka, PJ, Stenvang, J & Wengel, J 2005, 'Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)', Nucleosides, nucleotides & nucleic acids, vol. 24, no. 5-7, pp. 397-400.

APA

Hrdlicka, P. J., Stenvang, J., & Wengel, J. (2005). Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd). Nucleosides, nucleotides & nucleic acids, 24(5-7), 397-400.

Vancouver

Hrdlicka PJ, Stenvang J, Wengel J. Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd). Nucleosides, nucleotides & nucleic acids. 2005;24(5-7):397-400.

Author

Hrdlicka, Patrick J ; Stenvang, Jan ; Wengel, Jesper. / Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd). In: Nucleosides, nucleotides & nucleic acids. 2005 ; Vol. 24, No. 5-7. pp. 397-400.

Bibtex

@article{bb2af42c11374852add8031b24cca327,
title = "Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)",
abstract = "A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0. 73 microM.",
keywords = "Antimetabolites, Antineoplastic Agents, Cell Line, Tumor, Chemistry, Pharmaceutical, Cytidine, Drug Design, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Models, Chemical, Neoplasms, Nucleic Acid Conformation, Uracil, Uridine",
author = "Hrdlicka, {Patrick J} and Jan Stenvang and Jesper Wengel",
year = "2005",
language = "English",
volume = "24",
pages = "397--400",
journal = "Nucleosides, Nucleotides and Nucleic Acids",
issn = "1525-7770",
publisher = "Taylor & Francis",
number = "5-7",

}

RIS

TY - JOUR

T1 - Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)

AU - Hrdlicka, Patrick J

AU - Stenvang, Jan

AU - Wengel, Jesper

PY - 2005

Y1 - 2005

N2 - A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0. 73 microM.

AB - A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0. 73 microM.

KW - Antimetabolites

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Chemistry, Pharmaceutical

KW - Cytidine

KW - Drug Design

KW - Drug Screening Assays, Antitumor

KW - Humans

KW - Inhibitory Concentration 50

KW - Models, Chemical

KW - Neoplasms

KW - Nucleic Acid Conformation

KW - Uracil

KW - Uridine

M3 - Journal article

C2 - 16247958

VL - 24

SP - 397

EP - 400

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

SN - 1525-7770

IS - 5-7

ER -

ID: 59322958