Synthesis and application of a new fluorous-tagged ammonia equivalent

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synthesis and application of a new fluorous-tagged ammonia equivalent. / Nielsen, Simon Dalsgaard; Smith, Garrick; Begtrup, Mikael; Kristensen, Jesper Langgaard.

In: Chemistry: A European Journal, Vol. 16, No. 15, 2010, p. 4557-4566.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, SD, Smith, G, Begtrup, M & Kristensen, JL 2010, 'Synthesis and application of a new fluorous-tagged ammonia equivalent', Chemistry: A European Journal, vol. 16, no. 15, pp. 4557-4566. https://doi.org/10.1002/chem.200903178

APA

Nielsen, S. D., Smith, G., Begtrup, M., & Kristensen, J. L. (2010). Synthesis and application of a new fluorous-tagged ammonia equivalent. Chemistry: A European Journal, 16(15), 4557-4566. https://doi.org/10.1002/chem.200903178

Vancouver

Nielsen SD, Smith G, Begtrup M, Kristensen JL. Synthesis and application of a new fluorous-tagged ammonia equivalent. Chemistry: A European Journal. 2010;16(15):4557-4566. https://doi.org/10.1002/chem.200903178

Author

Nielsen, Simon Dalsgaard ; Smith, Garrick ; Begtrup, Mikael ; Kristensen, Jesper Langgaard. / Synthesis and application of a new fluorous-tagged ammonia equivalent. In: Chemistry: A European Journal. 2010 ; Vol. 16, No. 15. pp. 4557-4566.

Bibtex

@article{a9d804f04b8e11df928f000ea68e967b,

title = "Synthesis and application of a new fluorous-tagged ammonia equivalent",

abstract = "A novel fluorous-tagged ammonia equivalent has been developed. It is based on a nitrogen-oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluorous N--O linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional dyspepsia. Itopride was synthesized with the aid of fluorous purification methods and the product was isolated in good overall yield, with high purity.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Nielsen, {Simon Dalsgaard} and Garrick Smith and Mikael Begtrup and Kristensen, {Jesper Langgaard}",

note = "Keywords: ammonia equivalents; cleavage reactions; flourous synthesis; itopride; molybdenum",

year = "2010",

doi = "10.1002/chem.200903178",

language = "English",

volume = "16",

pages = "4557--4566",

journal = "Chemistry: A European Journal",

issn = "0947-6539",

publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",

number = "15",

}

RIS

TY - JOUR

T1 - Synthesis and application of a new fluorous-tagged ammonia equivalent

AU - Nielsen, Simon Dalsgaard

AU - Smith, Garrick

AU - Begtrup, Mikael

AU - Kristensen, Jesper Langgaard

N1 - Keywords: ammonia equivalents; cleavage reactions; flourous synthesis; itopride; molybdenum

PY - 2010

Y1 - 2010

N2 - A novel fluorous-tagged ammonia equivalent has been developed. It is based on a nitrogen-oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluorous N--O linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional dyspepsia. Itopride was synthesized with the aid of fluorous purification methods and the product was isolated in good overall yield, with high purity.

AB - A novel fluorous-tagged ammonia equivalent has been developed. It is based on a nitrogen-oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluorous N--O linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional dyspepsia. Itopride was synthesized with the aid of fluorous purification methods and the product was isolated in good overall yield, with high purity.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/chem.200903178

DO - 10.1002/chem.200903178

M3 - Journal article

C2 - 20333716

VL - 16

SP - 4557

EP - 4566

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

IS - 15

ER -

ID: 19345237