Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures
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Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures. / Kolko, M; DeCoster, M A; de Turco, E B; Bazan, N G.
In: The Journal of Biological Chemistry, Vol. 271, No. 51, 20.12.1996, p. 32722-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures
AU - Kolko, M
AU - DeCoster, M A
AU - de Turco, E B
AU - Bazan, N G
PY - 1996/12/20
Y1 - 1996/12/20
N2 - Secretory and cytosolic phospholipases A2 (sPLA2 and cPLA2) may contribute to the release of arachidonic acid and other bioactive lipids, which are modulators of synaptic function. In primary cortical neuron cultures, neurotoxic cell death and [3H]arachidonate metabolism was studied after adding glutamate and sPLA2 from bee venom. sPLA2, at concentrations eliciting low neurotoxicity (
AB - Secretory and cytosolic phospholipases A2 (sPLA2 and cPLA2) may contribute to the release of arachidonic acid and other bioactive lipids, which are modulators of synaptic function. In primary cortical neuron cultures, neurotoxic cell death and [3H]arachidonate metabolism was studied after adding glutamate and sPLA2 from bee venom. sPLA2, at concentrations eliciting low neurotoxicity (
KW - Animals
KW - Arachidonic Acid
KW - Bee Venoms
KW - Cell Death
KW - Cells, Cultured
KW - Cerebral Cortex
KW - Dizocilpine Maleate
KW - Drug Synergism
KW - Glutamates
KW - Neurons
KW - Neurotoxins
KW - Phospholipases A
KW - Phospholipases A2
KW - Phospholipids
KW - Rats
U2 - 10.1074/jbc.271.51.32722
DO - 10.1074/jbc.271.51.32722
M3 - Journal article
C2 - 8955105
VL - 271
SP - 32722
EP - 32728
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 51
ER -
ID: 128615130