TY - JOUR

T1 - Syndecan receptors

T2 - Pericellular regulators in development and inflammatory disease

AU - Gopal, Sandeep

AU - Arokiasamy, Samantha

AU - Pataki, Csilla

AU - Whiteford, James R.

AU - Couchman, John R.

PY - 2021/2/2

Y1 - 2021/2/2

N2 - The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both vertebrates and invertebrates have shown that syndecans link to the actin cytoskeleton and can fine-tune cell adhesion, migration, junction formation, polarity and differentiation. Although often associated as co-receptors with other classes of receptors (e.g. integrins, growth factor and morphogen receptors), syndecans can nonetheless signal to the cytoplasm in discrete ways. Syndecan expression levels are upregulated in development, tissue repair and an array of human diseases, which has led to the increased appreciation that they may be important in pathogenesis not only as diagnostic or prognostic agents, but also as potential targets. Here, their functions in development and inflammatory diseases are summarized, including their potential roles as conduits for viral pathogen entry into cells.

AB - The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both vertebrates and invertebrates have shown that syndecans link to the actin cytoskeleton and can fine-tune cell adhesion, migration, junction formation, polarity and differentiation. Although often associated as co-receptors with other classes of receptors (e.g. integrins, growth factor and morphogen receptors), syndecans can nonetheless signal to the cytoplasm in discrete ways. Syndecan expression levels are upregulated in development, tissue repair and an array of human diseases, which has led to the increased appreciation that they may be important in pathogenesis not only as diagnostic or prognostic agents, but also as potential targets. Here, their functions in development and inflammatory diseases are summarized, including their potential roles as conduits for viral pathogen entry into cells.

KW - cell adhesion

KW - glycosaminoglycan

KW - heparan sulfate

KW - inflammation

KW - proteoglycan

KW - stem cell

UR - http://www.scopus.com/inward/record.url?scp=85101454674&partnerID=8YFLogxK

U2 - 10.1098/rsob.200377

DO - 10.1098/rsob.200377

M3 - Review

C2 - 33561383

AN - SCOPUS:85101454674

VL - 11

JO - Open Biology

JF - Open Biology

SN - 2046-2441

IS - 2

M1 - 200377

ER -