TY - JOUR

T1 - Supplementation of docosahexaenoic acid (DHA), vitamin D3 and uridine in combination with six weeks of cognitive and motor training in prepubescent children

T2 - A pilot study

AU - Hansen, Solvejg Lis

AU - Ritterband-Rosenbaum, Anina

AU - Voigt, Camilla B

AU - Hellgren, Lars

AU - Sørensen, Ann-Dorit Moltke

AU - Jacobsen, Charlotte

AU - Greve, Line Z

AU - Jørgensen, Katrine D

AU - Bilde, Peder Esben

AU - Kiens, Bente

AU - Nielsen, Jens Bo

N1 - CURIS 2018 NEXS 343

PY - 2017

Y1 - 2017

N2 - Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise programwith dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D3 and 1000 mg uridine (DDU-supplement) in 16 prepubescent children (age 8–11 years).Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDUsupplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed.Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D2+3 and DHA (p = 0.023 and p < 0.001, respectively). Power calculation based on one of the cognitive tasksrevealed a proper sample size of 26 children.Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However,DDU-supplementation did result in increased blood concentration of DHA and vitamin D2+3.

AB - Background: Learning and memory have been shown to be influenced by combination of dietary supplements and exercise in animal models, but there is little available evidence from human subjects. The aim of this pilot study was to investigate the effect of combining a motor- and cognitive exercise programwith dietary supplementation consisting of 500 mg docosahexaenoic acid (DHA), 10 μg vitamin D3 and 1000 mg uridine (DDU-supplement) in 16 prepubescent children (age 8–11 years).Methods: We designed a randomized, placebo-controlled, double-blinded study lasting 6 weeks in which DDUsupplement or placebo was ingested daily. During the intervention period, all children trained approximately 30 min 3 days/week using an internet-based cognitive and motor training program (Mitii). Prior to and post the intervention period dietary record, blood sampling, physical exercise tests and motor and cognitive tests were performed.Results: Fourteen of the 16 children completed the intervention and ingested the supplement as required. 6 weeks DDU-supplementation resulted in a significant increase in the blood concentration of vitamin D2+3 and DHA (p = 0.023 and p < 0.001, respectively). Power calculation based on one of the cognitive tasksrevealed a proper sample size of 26 children.Conclusion: All children showed improved performance in the trained motor- and cognitive tasks, but it was not possible to demonstrate any significant effects on the cognitive tests from the dietary supplementation. However,DDU-supplementation did result in increased blood concentration of DHA and vitamin D2+3.

KW - Faculty of Science

KW - Nutritional supplement

KW - Training

KW - Children

KW - Blood samples

KW - DHA

KW - Vitamin D

KW - Uridine

KW - Pilot study

U2 - 10.1186/s40795-017-0155-1

DO - 10.1186/s40795-017-0155-1

M3 - Journal article

VL - 3

JO - B M C Nutrition

JF - B M C Nutrition

SN - 2055-0928

M1 - 37

ER -