Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

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Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. / Wellner, Niels; Tsuboi, Kazuhito; Madsen, Andreas Nygaard; Holst, Birgitte; Diep, Thi Ai; Nakao, Michiyasu; Tokumura, Akira; Burns, Matthew P; Deutsch, Dale G; Ueda, Natsuo; Hansen, Harald Severin.

In: BBA General Subjects, Vol. 1811, No. 9, 01.09.2011, p. 508-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wellner, N, Tsuboi, K, Madsen, AN, Holst, B, Diep, TA, Nakao, M, Tokumura, A, Burns, MP, Deutsch, DG, Ueda, N & Hansen, HS 2011, 'Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice', BBA General Subjects, vol. 1811, no. 9, pp. 508-12. https://doi.org/10.1016/j.bbalip.2011.06.020

APA

Wellner, N., Tsuboi, K., Madsen, A. N., Holst, B., Diep, T. A., Nakao, M., Tokumura, A., Burns, M. P., Deutsch, D. G., Ueda, N., & Hansen, H. S. (2011). Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. BBA General Subjects, 1811(9), 508-12. https://doi.org/10.1016/j.bbalip.2011.06.020

Vancouver

Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M et al. Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. BBA General Subjects. 2011 Sep 1;1811(9):508-12. https://doi.org/10.1016/j.bbalip.2011.06.020

Author

Wellner, Niels ; Tsuboi, Kazuhito ; Madsen, Andreas Nygaard ; Holst, Birgitte ; Diep, Thi Ai ; Nakao, Michiyasu ; Tokumura, Akira ; Burns, Matthew P ; Deutsch, Dale G ; Ueda, Natsuo ; Hansen, Harald Severin. / Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. In: BBA General Subjects. 2011 ; Vol. 1811, No. 9. pp. 508-12.

Bibtex

@article{9a355daf7e61400d9fd5aa733bac3d0a,

title = "Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice",

abstract = "N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific.",

author = "Niels Wellner and Kazuhito Tsuboi and Madsen, {Andreas Nygaard} and Birgitte Holst and Diep, {Thi Ai} and Michiyasu Nakao and Akira Tokumura and Burns, {Matthew P} and Deutsch, {Dale G} and Natsuo Ueda and Hansen, {Harald Severin}",

year = "2011",

month = sep,

day = "1",

doi = "10.1016/j.bbalip.2011.06.020",

language = "English",

volume = "1811",

pages = "508--12",

journal = "B B A - General Subjects",

issn = "0304-4165",

publisher = "Elsevier",

number = "9",

}

RIS

TY - JOUR

T1 - Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

AU - Wellner, Niels

AU - Tsuboi, Kazuhito

AU - Madsen, Andreas Nygaard

AU - Holst, Birgitte

AU - Diep, Thi Ai

AU - Nakao, Michiyasu

AU - Tokumura, Akira

AU - Burns, Matthew P

AU - Deutsch, Dale G

AU - Ueda, Natsuo

AU - Hansen, Harald Severin

PY - 2011/9/1

Y1 - 2011/9/1

N2 - N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific.

AB - N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific.

U2 - 10.1016/j.bbalip.2011.06.020

DO - 10.1016/j.bbalip.2011.06.020

M3 - Journal article

C2 - 21723414

VL - 1811

SP - 508

EP - 512

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 9

ER -

ID: 33802356