STRING 7--recent developments in the integration and prediction of protein interactions
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STRING 7--recent developments in the integration and prediction of protein interactions. / von Mering, Christian; Jensen, Lars J; Kuhn, Michael; Chaffron, Samuel; Doerks, Tobias; Krüger, Beate; Snel, Berend; Bork, Peer.
In: Nucleic Acids Research, Vol. 35, No. Database issue, 2007, p. D358-62.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - STRING 7--recent developments in the integration and prediction of protein interactions
AU - von Mering, Christian
AU - Jensen, Lars J
AU - Kuhn, Michael
AU - Chaffron, Samuel
AU - Doerks, Tobias
AU - Krüger, Beate
AU - Snel, Berend
AU - Bork, Peer
PY - 2007
Y1 - 2007
N2 - Information on protein-protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more than 1.5 million proteins for which associations have been pre-computed. Novel features include AJAX-based web-navigation, inclusion of additional resources such as BioGRID, and detailed protein domain annotation. STRING is available at http://string.embl.de/
AB - Information on protein-protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more than 1.5 million proteins for which associations have been pre-computed. Novel features include AJAX-based web-navigation, inclusion of additional resources such as BioGRID, and detailed protein domain annotation. STRING is available at http://string.embl.de/
U2 - 10.1093/nar/gkl825
DO - 10.1093/nar/gkl825
M3 - Journal article
C2 - 17098935
VL - 35
SP - D358-62
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - Database issue
ER -
ID: 40749068