STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Research output: Contribution to journal › Journal article › Research › peer-review
Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential biomarkers for risk stratification, by utilizing a gene co-expression network of transcriptomics data in addition to laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation of oxidative phosphorylation (OXPHOS) in PCa on the transcriptomic level and up-regulation of the TCA cycle/OXPHOS on the proteomic level, which is inversely correlated to STAT3 expression. We hereby identify gene expression of pyruvate dehydrogenase kinase 4 (PDK4), a key regulator of the TCA cycle, as a promising independent prognostic marker in PCa. PDK4 predicts disease recurrence independent of diagnostic risk factors such as grading, staging, and PSA level. Therefore, low PDK4 is a promising marker for PCa with dismal prognosis.
Original language | English |
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Journal | Molecular Systems Biology |
Volume | 16 |
Issue number | 4 |
Pages (from-to) | e9247 |
ISSN | 1744-4292 |
DOIs | |
Publication status | Published - Apr 2020 |
Externally published | Yes |
Bibliographical note
© 2020 The Authors. Published under the terms of the CC BY 4.0 license.
ID: 240409334