STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

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STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. / Zhang, Qian; Wang, Hong Y.; Marzec, Michal; Raghunath, Puthiyaveettil N.; Nagasawa, Tomohiko; Wasik, Mariusz A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 19, 2005, p. 6948-6953.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, Q, Wang, HY, Marzec, M, Raghunath, PN, Nagasawa, T & Wasik, MA 2005, 'STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 19, pp. 6948-6953. https://doi.org/10.1073/pnas.0501959102

APA

Zhang, Q., Wang, H. Y., Marzec, M., Raghunath, P. N., Nagasawa, T., & Wasik, M. A. (2005). STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America, 102(19), 6948-6953. https://doi.org/10.1073/pnas.0501959102

Vancouver

Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA. STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(19):6948-6953. https://doi.org/10.1073/pnas.0501959102

Author

Zhang, Qian ; Wang, Hong Y. ; Marzec, Michal ; Raghunath, Puthiyaveettil N. ; Nagasawa, Tomohiko ; Wasik, Mariusz A. / STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 19. pp. 6948-6953.

Bibtex

@article{89506356155f427fae070d26cf91d4ad,

title = "STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.",

abstract = "Expression of SHP-1 phosphatase, a key neg. regulator of cell signaling, is lost in T cell lymphomas and other malignancies due to DNA methylation of the SHP-1 promoter by a currently undefined mechanism. The authors demonstrate that malignant T cells express DNA methyltransferase (DNMT) 1 and that constantly activated signal transducer and activator of transcription (STAT) 3 is capable of binding in vitro to DNA oligonucleotides corresponding to 4 STAT3 SIE/GAS binding sites identified in the SHP-1 promoter. STAT3, DNMT1, and histone deacetylase 1 form complexes and bind to the SHP-1 promoter in vivo. Treatment with pharmacol. grade DNMT1 anti-sense oligonucleotides and STAT3 small-interfering RNA induces in the malignant T cells DNA demethylation and expression of SHP-1 gene. These data indicate that STAT3 may, in part, transform cells by inducing epigenetic silencing of SHP-1 in cooperation with DNMT1 and, apparently, histone deacetylase 1. Reversal of such gene silencing represents an attractive aim for novel anticancer therapies. [on SciFinder(R)]",

keywords = "gene silencing STAT3 DNA methyltransferase SHP1 lymphoma, histone diacetylase STAT3 SHP1 methylation lymphoma",

author = "Qian Zhang and Wang, {Hong Y.} and Michal Marzec and Raghunath, {Puthiyaveettil N.} and Tomohiko Nagasawa and Wasik, {Mariusz A.}",

year = "2005",

doi = "10.1073/pnas.0501959102",

language = "English",

volume = "102",

pages = "6948--6953",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "The National Academy of Sciences of the United States of America",

number = "19",

}

RIS

TY - JOUR

T1 - STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

AU - Zhang, Qian

AU - Wang, Hong Y.

AU - Marzec, Michal

AU - Raghunath, Puthiyaveettil N.

AU - Nagasawa, Tomohiko

AU - Wasik, Mariusz A.

PY - 2005

Y1 - 2005

N2 - Expression of SHP-1 phosphatase, a key neg. regulator of cell signaling, is lost in T cell lymphomas and other malignancies due to DNA methylation of the SHP-1 promoter by a currently undefined mechanism. The authors demonstrate that malignant T cells express DNA methyltransferase (DNMT) 1 and that constantly activated signal transducer and activator of transcription (STAT) 3 is capable of binding in vitro to DNA oligonucleotides corresponding to 4 STAT3 SIE/GAS binding sites identified in the SHP-1 promoter. STAT3, DNMT1, and histone deacetylase 1 form complexes and bind to the SHP-1 promoter in vivo. Treatment with pharmacol. grade DNMT1 anti-sense oligonucleotides and STAT3 small-interfering RNA induces in the malignant T cells DNA demethylation and expression of SHP-1 gene. These data indicate that STAT3 may, in part, transform cells by inducing epigenetic silencing of SHP-1 in cooperation with DNMT1 and, apparently, histone deacetylase 1. Reversal of such gene silencing represents an attractive aim for novel anticancer therapies. [on SciFinder(R)]

AB - Expression of SHP-1 phosphatase, a key neg. regulator of cell signaling, is lost in T cell lymphomas and other malignancies due to DNA methylation of the SHP-1 promoter by a currently undefined mechanism. The authors demonstrate that malignant T cells express DNA methyltransferase (DNMT) 1 and that constantly activated signal transducer and activator of transcription (STAT) 3 is capable of binding in vitro to DNA oligonucleotides corresponding to 4 STAT3 SIE/GAS binding sites identified in the SHP-1 promoter. STAT3, DNMT1, and histone deacetylase 1 form complexes and bind to the SHP-1 promoter in vivo. Treatment with pharmacol. grade DNMT1 anti-sense oligonucleotides and STAT3 small-interfering RNA induces in the malignant T cells DNA demethylation and expression of SHP-1 gene. These data indicate that STAT3 may, in part, transform cells by inducing epigenetic silencing of SHP-1 in cooperation with DNMT1 and, apparently, histone deacetylase 1. Reversal of such gene silencing represents an attractive aim for novel anticancer therapies. [on SciFinder(R)]

KW - gene silencing STAT3 DNA methyltransferase SHP1 lymphoma

KW - histone diacetylase STAT3 SHP1 methylation lymphoma

U2 - 10.1073/pnas.0501959102

DO - 10.1073/pnas.0501959102

M3 - Journal article

VL - 102

SP - 6948

EP - 6953

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 19

ER -

ID: 202376345