Soluble interleukin-2 receptors in ulcerative colitis

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Standard

Soluble interleukin-2 receptors in ulcerative colitis. / Nielsen, O H; Brynskov, J.

In: Mediators of Inflammation, Vol. 2, No. 2, 1993, p. 115-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, OH & Brynskov, J 1993, 'Soluble interleukin-2 receptors in ulcerative colitis', Mediators of Inflammation, vol. 2, no. 2, pp. 115-8. https://doi.org/10.1155/S096293519300016X

APA

Nielsen, O. H., & Brynskov, J. (1993). Soluble interleukin-2 receptors in ulcerative colitis. Mediators of Inflammation, 2(2), 115-8. https://doi.org/10.1155/S096293519300016X

Vancouver

Nielsen OH, Brynskov J. Soluble interleukin-2 receptors in ulcerative colitis. Mediators of Inflammation. 1993;2(2):115-8. https://doi.org/10.1155/S096293519300016X

Author

Nielsen, O H ; Brynskov, J. / Soluble interleukin-2 receptors in ulcerative colitis. In: Mediators of Inflammation. 1993 ; Vol. 2, No. 2. pp. 115-8.

Bibtex

@article{7a8a4fcb07b74c6991f5a4ffbbf3134c,
title = "Soluble interleukin-2 receptors in ulcerative colitis",
abstract = "T-Cell activation results in the release or shedding of a soluble form (45 kDa) of the cellular (55 kDa) low-affinity interleukin-2 receptor (alpha-chain) (slL-2R). The present study was performed to investigate if the serum concentration of sIL-2R is a marker of disease activity in patients with ulcerative colitis (UC), a chronic inflammatory bowel disease. Twenty-seven UC patients (about half of them in remission) and 13 healthy volunteers were studied, sIL-2R concentrations were measured by an enzyme-linked immunosorbent assay, and significantly elevated median sIL-2R values were found in clinically active UC (150 pg/ml; range 100-420), compared to inactive UC (145 pg/ml; range 110-255), and healthy controls (110 pg/ml; range 80-165) (p < 0.01). There was no correlation between sIL-2R concentrations and extent of the disease. Due to the overlap of serum sIL-2R concentrations between different disease stages and controls, the general diagnostic value seems to be limited. However, since slL-2R release is an IL-2 dependent phenomenon, we conclude that the demonstration of increased serum sIL-2R concentrations in UC suggests the existence of an enhanced T-cell activation in vivo in this disease. Further longitudinal studies are required to elucidate if repeated measurements of sIL-2R levels provide an additional way of monitoring UC disease activity in individual patients.",
author = "Nielsen, {O H} and J Brynskov",
year = "1993",
doi = "10.1155/S096293519300016X",
language = "English",
volume = "2",
pages = "115--8",
journal = "Mediators of Inflammation",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",
number = "2",

}

RIS

TY - JOUR

T1 - Soluble interleukin-2 receptors in ulcerative colitis

AU - Nielsen, O H

AU - Brynskov, J

PY - 1993

Y1 - 1993

N2 - T-Cell activation results in the release or shedding of a soluble form (45 kDa) of the cellular (55 kDa) low-affinity interleukin-2 receptor (alpha-chain) (slL-2R). The present study was performed to investigate if the serum concentration of sIL-2R is a marker of disease activity in patients with ulcerative colitis (UC), a chronic inflammatory bowel disease. Twenty-seven UC patients (about half of them in remission) and 13 healthy volunteers were studied, sIL-2R concentrations were measured by an enzyme-linked immunosorbent assay, and significantly elevated median sIL-2R values were found in clinically active UC (150 pg/ml; range 100-420), compared to inactive UC (145 pg/ml; range 110-255), and healthy controls (110 pg/ml; range 80-165) (p < 0.01). There was no correlation between sIL-2R concentrations and extent of the disease. Due to the overlap of serum sIL-2R concentrations between different disease stages and controls, the general diagnostic value seems to be limited. However, since slL-2R release is an IL-2 dependent phenomenon, we conclude that the demonstration of increased serum sIL-2R concentrations in UC suggests the existence of an enhanced T-cell activation in vivo in this disease. Further longitudinal studies are required to elucidate if repeated measurements of sIL-2R levels provide an additional way of monitoring UC disease activity in individual patients.

AB - T-Cell activation results in the release or shedding of a soluble form (45 kDa) of the cellular (55 kDa) low-affinity interleukin-2 receptor (alpha-chain) (slL-2R). The present study was performed to investigate if the serum concentration of sIL-2R is a marker of disease activity in patients with ulcerative colitis (UC), a chronic inflammatory bowel disease. Twenty-seven UC patients (about half of them in remission) and 13 healthy volunteers were studied, sIL-2R concentrations were measured by an enzyme-linked immunosorbent assay, and significantly elevated median sIL-2R values were found in clinically active UC (150 pg/ml; range 100-420), compared to inactive UC (145 pg/ml; range 110-255), and healthy controls (110 pg/ml; range 80-165) (p < 0.01). There was no correlation between sIL-2R concentrations and extent of the disease. Due to the overlap of serum sIL-2R concentrations between different disease stages and controls, the general diagnostic value seems to be limited. However, since slL-2R release is an IL-2 dependent phenomenon, we conclude that the demonstration of increased serum sIL-2R concentrations in UC suggests the existence of an enhanced T-cell activation in vivo in this disease. Further longitudinal studies are required to elucidate if repeated measurements of sIL-2R levels provide an additional way of monitoring UC disease activity in individual patients.

U2 - 10.1155/S096293519300016X

DO - 10.1155/S096293519300016X

M3 - Journal article

C2 - 18475512

VL - 2

SP - 115

EP - 118

JO - Mediators of Inflammation

JF - Mediators of Inflammation

SN - 0962-9351

IS - 2

ER -

ID: 218727615