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SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice. / Zadjali, Fahad; Santana-Farre, Ruyman; Vesterlund, Mattias; Carow, Berit; Mirecki-Garrido, Mercedes; Hernandez-Hernandez, Irene; Flodström-Tullberg, Malin; Parini, Paolo; Rottenberg, Martin; Norstedt, Gunnar; Fernandez-Perez, Leandro; Flores Morales, Amilcar.
In:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, No. 8, 2012, p. 3282-91.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Zadjali, F, Santana-Farre, R, Vesterlund, M, Carow, B, Mirecki-Garrido, M, Hernandez-Hernandez, I, Flodström-Tullberg, M, Parini, P, Rottenberg, M, Norstedt, G, Fernandez-Perez, L & Flores Morales, A 2012, '
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice',
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 26, no. 8, pp. 3282-91.
https://doi.org/10.1096/fj.12-205583APA
Zadjali, F., Santana-Farre, R., Vesterlund, M., Carow, B., Mirecki-Garrido, M., Hernandez-Hernandez, I., Flodström-Tullberg, M., Parini, P., Rottenberg, M., Norstedt, G., Fernandez-Perez, L., & Flores Morales, A. (2012).
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
26(8), 3282-91.
https://doi.org/10.1096/fj.12-205583Vancouver
Zadjali F, Santana-Farre R, Vesterlund M, Carow B, Mirecki-Garrido M, Hernandez-Hernandez I et al.
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012;26(8):3282-91.
https://doi.org/10.1096/fj.12-205583Author
Zadjali, Fahad ; Santana-Farre, Ruyman ; Vesterlund, Mattias ; Carow, Berit ; Mirecki-Garrido, Mercedes ; Hernandez-Hernandez, Irene ; Flodström-Tullberg, Malin ; Parini, Paolo ; Rottenberg, Martin ; Norstedt, Gunnar ; Fernandez-Perez, Leandro ; Flores Morales, Amilcar. / SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice. In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 ; Vol. 26, No. 8. pp. 3282-91.
Bibtex
@article{62f3c63da8304a0bbba357cf2756dea5,
title = "SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice",
abstract = "Hepatic steatosis is a prominent feature in patients with growth hormone (GH) deficiency. The ubiquitin ligase SOCS2 attenuates hepatic GH signaling by inhibiting the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5b (STAT5b) axis. Here, we investigated the role of SOCS2 in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice exhibited increased hepatic TG secretion by 77.6% (P",
keywords = "Animals, Diet, High-Fat, Fatty Liver, Insulin Resistance, Interferon-gamma, Interleukin-6, Lipid Metabolism, Liver, Male, Mice, Mice, Knockout, NF-kappa B, Suppressor of Cytokine Signaling Proteins, Toll-Like Receptor 4, Triglycerides",
author = "Fahad Zadjali and Ruyman Santana-Farre and Mattias Vesterlund and Berit Carow and Mercedes Mirecki-Garrido and Irene Hernandez-Hernandez and Malin Flodstr{\"o}m-Tullberg and Paolo Parini and Martin Rottenberg and Gunnar Norstedt and Leandro Fernandez-Perez and {Flores Morales}, Amilcar",
year = "2012",
doi = "10.1096/fj.12-205583",
language = "English",
volume = "26",
pages = "3282--91",
journal = "F A S E B Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "8",
}
RIS
TY - JOUR
T1 - SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice
AU - Zadjali, Fahad
AU - Santana-Farre, Ruyman
AU - Vesterlund, Mattias
AU - Carow, Berit
AU - Mirecki-Garrido, Mercedes
AU - Hernandez-Hernandez, Irene
AU - Flodström-Tullberg, Malin
AU - Parini, Paolo
AU - Rottenberg, Martin
AU - Norstedt, Gunnar
AU - Fernandez-Perez, Leandro
AU - Flores Morales, Amilcar
PY - 2012
Y1 - 2012
N2 - Hepatic steatosis is a prominent feature in patients with growth hormone (GH) deficiency. The ubiquitin ligase SOCS2 attenuates hepatic GH signaling by inhibiting the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5b (STAT5b) axis. Here, we investigated the role of SOCS2 in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice exhibited increased hepatic TG secretion by 77.6% (P
AB - Hepatic steatosis is a prominent feature in patients with growth hormone (GH) deficiency. The ubiquitin ligase SOCS2 attenuates hepatic GH signaling by inhibiting the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5b (STAT5b) axis. Here, we investigated the role of SOCS2 in the development of diet-induced hepatic steatosis and insulin resistance. SOCS2-knockout (SOCS2(-/-)) mice and wild-type littermates were fed for 4 mo with control or high-fat diet, followed by assessment of insulin sensitivity, hepatic lipid content, and expression of inflammatory cytokines. SOCS2(-/-) mice exhibited increased hepatic TG secretion by 77.6% (P
KW - Animals
KW - Diet, High-Fat
KW - Fatty Liver
KW - Insulin Resistance
KW - Interferon-gamma
KW - Interleukin-6
KW - Lipid Metabolism
KW - Liver
KW - Male
KW - Mice
KW - Mice, Knockout
KW - NF-kappa B
KW - Suppressor of Cytokine Signaling Proteins
KW - Toll-Like Receptor 4
KW - Triglycerides
U2 - 10.1096/fj.12-205583
DO - 10.1096/fj.12-205583
M3 - Journal article
C2 - 22562833
VL - 26
SP - 3282
EP - 3291
JO - F A S E B Journal
JF - F A S E B Journal
SN - 0892-6638
IS - 8
ER -
