Site-selective three-component reaction for dual-functionalization of peptides
Research output: Contribution to journal › Journal article › Research › peer-review
A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.
Original language | English |
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Journal | Chemical Communications |
Volume | 49 |
Issue number | 19 |
Pages (from-to) | 1936-1938 |
Number of pages | 3 |
ISSN | 1359-7345 |
DOIs | |
Publication status | Published - 2013 |
ID: 88717747