Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia
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Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia. / Alanin, Mikkel Christian; Johansen, Helle Krogh; Aanaes, Kasper; Høiby, Niels; Pressler, Tanja; Skov, Marianne; Nielsen, Kim Gjerum; von Buchwald, Christian.
In: Acta Oto-Laryngologica, Vol. 135, No. 1, 01.2015, p. 58-63.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Simultaneous sinus and lung infections in patients with primary ciliary dyskinesia
AU - Alanin, Mikkel Christian
AU - Johansen, Helle Krogh
AU - Aanaes, Kasper
AU - Høiby, Niels
AU - Pressler, Tanja
AU - Skov, Marianne
AU - Nielsen, Kim Gjerum
AU - von Buchwald, Christian
PY - 2015/1
Y1 - 2015/1
N2 - CONCLUSION: The sinuses should be considered as a bacterial reservoir and a target for surgery and antibiotic treatment in patients with primary ciliary dyskinesia (PCD). The observed decrease in serum precipitating antibodies (precipitins) against Pseudomonas aeruginosa may indicate a beneficial effect of combined endoscopic sinus surgery (ESS) and concomitant medical treatment.OBJECTIVES: The purpose of this research, which is the first study addressing bacteriology in the sinuses of patients with PCD, was to examine the association between sinus and lung infections.METHODS: We reviewed findings of bacterial pathogens from the sinuses obtained during ESS and the lung infection status in eight PCD patients over a 6 year period. Precipitins against P. aeruginosa were used as a marker of severity of chronic infection and effect of treatment.RESULTS: Preoperatively, seven of the eight patients (88%) exhibited intermittent or chronic pulmonary infection with P. aeruginosa. Sinus cultures were obtained during ESS in seven patients. The sinuses were colonized with P. aeruginosa in four of seven patients (57%). Bacterial sinusitis was found in five of seven patients (71%) and the same bacterium was found in the sinuses and lungs in all cases. Decreasing precipitins against P. aeruginosa were observed postoperatively in three of four evaluable patients.
AB - CONCLUSION: The sinuses should be considered as a bacterial reservoir and a target for surgery and antibiotic treatment in patients with primary ciliary dyskinesia (PCD). The observed decrease in serum precipitating antibodies (precipitins) against Pseudomonas aeruginosa may indicate a beneficial effect of combined endoscopic sinus surgery (ESS) and concomitant medical treatment.OBJECTIVES: The purpose of this research, which is the first study addressing bacteriology in the sinuses of patients with PCD, was to examine the association between sinus and lung infections.METHODS: We reviewed findings of bacterial pathogens from the sinuses obtained during ESS and the lung infection status in eight PCD patients over a 6 year period. Precipitins against P. aeruginosa were used as a marker of severity of chronic infection and effect of treatment.RESULTS: Preoperatively, seven of the eight patients (88%) exhibited intermittent or chronic pulmonary infection with P. aeruginosa. Sinus cultures were obtained during ESS in seven patients. The sinuses were colonized with P. aeruginosa in four of seven patients (57%). Bacterial sinusitis was found in five of seven patients (71%) and the same bacterium was found in the sinuses and lungs in all cases. Decreasing precipitins against P. aeruginosa were observed postoperatively in three of four evaluable patients.
KW - Adolescent
KW - Adult
KW - Child
KW - Chronic Disease
KW - Disease Reservoirs
KW - Endoscopy
KW - Female
KW - Humans
KW - Kartagener Syndrome
KW - Lung
KW - Male
KW - Middle Aged
KW - Paranasal Sinuses
KW - Pseudomonas Infections
KW - Pseudomonas aeruginosa
KW - Retrospective Studies
KW - Sinusitis
KW - Young Adult
U2 - 10.3109/00016489.2014.962185
DO - 10.3109/00016489.2014.962185
M3 - Journal article
C2 - 25370419
VL - 135
SP - 58
EP - 63
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 1
ER -
ID: 162347204