Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer. / Borgwardt, Henrik Gutte; Hansen, Adam Espe; Larsen, Majbrit M. E.; Rahbek, Sofie; Henriksen, Sarah T.; Johannesen, Helle Hjorth; Ardenkjær-Larsen, Jan Henrik; Kristensen, Annemarie Thuri; Højgaard, Liselotte; Kjær, Andreas.

In: Journal of Nuclear Medicine, Vol. 56, No. 11, 11.2015, p. 1786-92.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Borgwardt, HG, Hansen, AE, Larsen, MME, Rahbek, S, Henriksen, ST, Johannesen, HH, Ardenkjær-Larsen, JH, Kristensen, AT, Højgaard, L & Kjær, A 2015, 'Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer', Journal of Nuclear Medicine, vol. 56, no. 11, pp. 1786-92. https://doi.org/10.2967/jnumed.115.156364

APA

Borgwardt, H. G., Hansen, A. E., Larsen, M. M. E., Rahbek, S., Henriksen, S. T., Johannesen, H. H., Ardenkjær-Larsen, J. H., Kristensen, A. T., Højgaard, L., & Kjær, A. (2015). Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer. Journal of Nuclear Medicine, 56(11), 1786-92. https://doi.org/10.2967/jnumed.115.156364

Vancouver

Borgwardt HG, Hansen AE, Larsen MME, Rahbek S, Henriksen ST, Johannesen HH et al. Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer. Journal of Nuclear Medicine. 2015 Nov;56(11):1786-92. https://doi.org/10.2967/jnumed.115.156364

Author

Borgwardt, Henrik Gutte ; Hansen, Adam Espe ; Larsen, Majbrit M. E. ; Rahbek, Sofie ; Henriksen, Sarah T. ; Johannesen, Helle Hjorth ; Ardenkjær-Larsen, Jan Henrik ; Kristensen, Annemarie Thuri ; Højgaard, Liselotte ; Kjær, Andreas. / Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer. In: Journal of Nuclear Medicine. 2015 ; Vol. 56, No. 11. pp. 1786-92.

Bibtex

@article{13602fcb242941aba54f840d1dde46b0,
title = "Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer",
abstract = "With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.",
keywords = "cancer, dynamic nuclear polarization, hyperpolarized, 13C-pyruvate, MR, 18F-FDG PET, PET/MR, molecular imaging",
author = "Borgwardt, {Henrik Gutte} and Hansen, {Adam Espe} and Larsen, {Majbrit M. E.} and Sofie Rahbek and Henriksen, {Sarah T.} and Johannesen, {Helle Hjorth} and Ardenkj{\ae}r-Larsen, {Jan Henrik} and Kristensen, {Annemarie Thuri} and Liselotte H{\o}jgaard and Andreas Kj{\ae}r",
note = "{\textcopyright} 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",
year = "2015",
month = nov,
doi = "10.2967/jnumed.115.156364",
language = "English",
volume = "56",
pages = "1786--92",
journal = "The Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine",
number = "11",

}

RIS

TY - JOUR

T1 - Simultaneous hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 dogs with cancer

AU - Borgwardt, Henrik Gutte

AU - Hansen, Adam Espe

AU - Larsen, Majbrit M. E.

AU - Rahbek, Sofie

AU - Henriksen, Sarah T.

AU - Johannesen, Helle Hjorth

AU - Ardenkjær-Larsen, Jan Henrik

AU - Kristensen, Annemarie Thuri

AU - Højgaard, Liselotte

AU - Kjær, Andreas

N1 - © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

PY - 2015/11

Y1 - 2015/11

N2 - With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.

AB - With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study was to establish a practical workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously for tumor tissue characterization and on a larger scale test its feasibility. In addition, we evaluated the correlation between (18)F-FDG uptake and (13)C-lactate production.METHODS: Ten dogs with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner.RESULTS: We found that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C-lactate production in 9 of 10 dogs. For the 9 dogs, the (13)C-lactate was detected after a mean of 25 s (range, 17-33 s), with a mean to peak of (13)C-lactate at 49 s (range, 40-62 s). (13)C-pyruvate could be detected on average after 13 s (range, 5-26 s) and peaked on average after 25 s (range, 13-42 s). We noticed concordance of (18)F-FDG uptake and production of (13)C-lactate in most, but not all, axial slices.CONCLUSION: In this study, we have shown in a series of dogs with cancer that hyperPET can easily be performed within 2 h. We showed mostly correspondence between (13)C-lactate production and (18)F-FDG uptake and expect the combined modalities to reveal additional metabolic information to improve prognostic value and improve response monitoring.

KW - cancer

KW - dynamic nuclear polarization

KW - hyperpolarized

KW - 13C-pyruvate

KW - MR

KW - 18F-FDG PET

KW - PET/MR

KW - molecular imaging

U2 - 10.2967/jnumed.115.156364

DO - 10.2967/jnumed.115.156364

M3 - Journal article

C2 - 26338899

VL - 56

SP - 1786

EP - 1792

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

SN - 0161-5505

IS - 11

ER -

ID: 160835157