Simplicity at the cost of predictive accuracy in diffuse large B-cell lymphoma: a critical assessment of the R-IPI, IPI, and NCCN-IPI
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Simplicity at the cost of predictive accuracy in diffuse large B-cell lymphoma : a critical assessment of the R-IPI, IPI, and NCCN-IPI. / Biccler, Jorne; Eloranta, Sandra; de Nully Brown, Peter; Frederiksen, Henrik; Jerkeman, Mats; Smedby, Karin E.; Bøgsted, Martin; El-Galaly, Tarec C.
In: Cancer Medicine, Vol. 7, No. 1, 01.2018, p. 114-122.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Simplicity at the cost of predictive accuracy in diffuse large B-cell lymphoma
T2 - a critical assessment of the R-IPI, IPI, and NCCN-IPI
AU - Biccler, Jorne
AU - Eloranta, Sandra
AU - de Nully Brown, Peter
AU - Frederiksen, Henrik
AU - Jerkeman, Mats
AU - Smedby, Karin E.
AU - Bøgsted, Martin
AU - El-Galaly, Tarec C.
PY - 2018/1
Y1 - 2018/1
N2 - The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI) to a Cox proportional hazards (CPH) model using the same covariates in nondichotomized form. All models were tested in 4863 newly diagnosed DLBCL patients from population-based Nordic registers. The CPH model led to a substantial increase in predictive accuracy as compared to conventional prognostic scores when evaluated by the area under the curve and other relevant tests. Furthermore, the generation of patient-specific survival curves rather than assigning patients to one of few predefined risk groups is a relevant step toward personalized management and treatment. A test-version is available on lymphomapredictor.org.
AB - The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI) to a Cox proportional hazards (CPH) model using the same covariates in nondichotomized form. All models were tested in 4863 newly diagnosed DLBCL patients from population-based Nordic registers. The CPH model led to a substantial increase in predictive accuracy as compared to conventional prognostic scores when evaluated by the area under the curve and other relevant tests. Furthermore, the generation of patient-specific survival curves rather than assigning patients to one of few predefined risk groups is a relevant step toward personalized management and treatment. A test-version is available on lymphomapredictor.org.
KW - Diffuse large B-cell lymphoma
KW - IPI
KW - prognosis
KW - prognostic factors
KW - risk modeling
U2 - 10.1002/cam4.1271
DO - 10.1002/cam4.1271
M3 - Journal article
C2 - 29239133
AN - SCOPUS:85038019372
VL - 7
SP - 114
EP - 122
JO - Cancer Medicine
JF - Cancer Medicine
SN - 2045-7634
IS - 1
ER -
ID: 189735749