Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes

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Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes. / Clausen, Peter; Ekbom, Pia; Damm, Peter; Feldt-Rasmussen, Ulla; Nielsen, Birthe; Mathiesen, Elisabeth R; Feldt-Rasmussen, Bo.

In: Journal of Diabetes and its Complications, Vol. 21, No. 5, 2007, p. 288-93.

Research output: Contribution to journalJournal articleResearch

Harvard

Clausen, P, Ekbom, P, Damm, P, Feldt-Rasmussen, U, Nielsen, B, Mathiesen, ER & Feldt-Rasmussen, B 2007, 'Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes', Journal of Diabetes and its Complications, vol. 21, no. 5, pp. 288-93. https://doi.org/10.1016/j.jdiacomp.2006.03.004, https://doi.org/10.1016/j.jdiacomp.2006.03.004

APA

Clausen, P., Ekbom, P., Damm, P., Feldt-Rasmussen, U., Nielsen, B., Mathiesen, E. R., & Feldt-Rasmussen, B. (2007). Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes. Journal of Diabetes and its Complications, 21(5), 288-93. https://doi.org/10.1016/j.jdiacomp.2006.03.004, https://doi.org/10.1016/j.jdiacomp.2006.03.004

Vancouver

Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER et al. Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes. Journal of Diabetes and its Complications. 2007;21(5):288-93. https://doi.org/10.1016/j.jdiacomp.2006.03.004, https://doi.org/10.1016/j.jdiacomp.2006.03.004

Author

Clausen, Peter ; Ekbom, Pia ; Damm, Peter ; Feldt-Rasmussen, Ulla ; Nielsen, Birthe ; Mathiesen, Elisabeth R ; Feldt-Rasmussen, Bo. / Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes. In: Journal of Diabetes and its Complications. 2007 ; Vol. 21, No. 5. pp. 288-93.

Bibtex

@article{1a3b944912584aadbccb8334302c03db,
title = "Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes",
abstract = "Aim This study aims to test the hypothesis that vascular dysfunction is present early in pregnancy in women with type 1 diabetes who subsequently develop preeclampsia. Methods Eighty-three women with type 1 diabetes of more than 10 years duration were followed up prospectively during pregnancy. External ultrasound was used to measure the dilatory response of the brachial artery to postischemic increased blood flow (endothelium-dependent, flow-associated dilatation) and to nitroglycerin (NTG) [endothelium-independent, NTG-induced dilatation (NID)] at Gestational Weeks 11 and 29. Plasma concentrations of the vascular markers vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, and von Willebrand factor antigen were also measured together with 24-h urinary albumin excretion (UAE), blood pressure (BP), and HbA1C. Results Fourteen (17{\%}) of the 83 women developed preeclampsia. NID was significantly impaired at Week 29 in women prone to preeclampsia (108.8±7.0{\%} vs. 116.8±8.9{\%}, mean±S.D., P<.05), and the plasma concentrations of VCAM-1 and ICAM-1 were significantly elevated at Gestational Week 11 (612±82 vs. 516±109 µg/l, P<.005 and 293±67 vs. 255±57 µg/l, P<.05, respectively). Women who later developed preeclampsia were also characterized by higher UAE, higher BP, and higher HbA1C than women who did not [Gestational Week 11: 194 (3–1104) vs. 7 (0–412) mg/24 h, median (range), P=.0003; 122±12/75±6 vs. 111±11/69±9 mmHg, mean±S.D., P<.01; and 8.2{\%} (5.9–10.5{\%}) vs. 7.2{\%} (5.3–10.9{\%}), P=.008, respectively]. Conclusion This prospective study indicates that signs of maternal vascular dysfunction precede development of preeclampsia in women with type 1 diabetes.",
author = "Peter Clausen and Pia Ekbom and Peter Damm and Ulla Feldt-Rasmussen and Birthe Nielsen and Mathiesen, {Elisabeth R} and Bo Feldt-Rasmussen",
year = "2007",
doi = "10.1016/j.jdiacomp.2006.03.004",
language = "English",
volume = "21",
pages = "288--93",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Signs of maternal vascular dysfunction precede preeclampsia in women with type 1 diabetes

AU - Clausen, Peter

AU - Ekbom, Pia

AU - Damm, Peter

AU - Feldt-Rasmussen, Ulla

AU - Nielsen, Birthe

AU - Mathiesen, Elisabeth R

AU - Feldt-Rasmussen, Bo

PY - 2007

Y1 - 2007

N2 - Aim This study aims to test the hypothesis that vascular dysfunction is present early in pregnancy in women with type 1 diabetes who subsequently develop preeclampsia. Methods Eighty-three women with type 1 diabetes of more than 10 years duration were followed up prospectively during pregnancy. External ultrasound was used to measure the dilatory response of the brachial artery to postischemic increased blood flow (endothelium-dependent, flow-associated dilatation) and to nitroglycerin (NTG) [endothelium-independent, NTG-induced dilatation (NID)] at Gestational Weeks 11 and 29. Plasma concentrations of the vascular markers vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, and von Willebrand factor antigen were also measured together with 24-h urinary albumin excretion (UAE), blood pressure (BP), and HbA1C. Results Fourteen (17%) of the 83 women developed preeclampsia. NID was significantly impaired at Week 29 in women prone to preeclampsia (108.8±7.0% vs. 116.8±8.9%, mean±S.D., P<.05), and the plasma concentrations of VCAM-1 and ICAM-1 were significantly elevated at Gestational Week 11 (612±82 vs. 516±109 µg/l, P<.005 and 293±67 vs. 255±57 µg/l, P<.05, respectively). Women who later developed preeclampsia were also characterized by higher UAE, higher BP, and higher HbA1C than women who did not [Gestational Week 11: 194 (3–1104) vs. 7 (0–412) mg/24 h, median (range), P=.0003; 122±12/75±6 vs. 111±11/69±9 mmHg, mean±S.D., P<.01; and 8.2% (5.9–10.5%) vs. 7.2% (5.3–10.9%), P=.008, respectively]. Conclusion This prospective study indicates that signs of maternal vascular dysfunction precede development of preeclampsia in women with type 1 diabetes.

AB - Aim This study aims to test the hypothesis that vascular dysfunction is present early in pregnancy in women with type 1 diabetes who subsequently develop preeclampsia. Methods Eighty-three women with type 1 diabetes of more than 10 years duration were followed up prospectively during pregnancy. External ultrasound was used to measure the dilatory response of the brachial artery to postischemic increased blood flow (endothelium-dependent, flow-associated dilatation) and to nitroglycerin (NTG) [endothelium-independent, NTG-induced dilatation (NID)] at Gestational Weeks 11 and 29. Plasma concentrations of the vascular markers vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, and von Willebrand factor antigen were also measured together with 24-h urinary albumin excretion (UAE), blood pressure (BP), and HbA1C. Results Fourteen (17%) of the 83 women developed preeclampsia. NID was significantly impaired at Week 29 in women prone to preeclampsia (108.8±7.0% vs. 116.8±8.9%, mean±S.D., P<.05), and the plasma concentrations of VCAM-1 and ICAM-1 were significantly elevated at Gestational Week 11 (612±82 vs. 516±109 µg/l, P<.005 and 293±67 vs. 255±57 µg/l, P<.05, respectively). Women who later developed preeclampsia were also characterized by higher UAE, higher BP, and higher HbA1C than women who did not [Gestational Week 11: 194 (3–1104) vs. 7 (0–412) mg/24 h, median (range), P=.0003; 122±12/75±6 vs. 111±11/69±9 mmHg, mean±S.D., P<.01; and 8.2% (5.9–10.5%) vs. 7.2% (5.3–10.9%), P=.008, respectively]. Conclusion This prospective study indicates that signs of maternal vascular dysfunction precede development of preeclampsia in women with type 1 diabetes.

U2 - 10.1016/j.jdiacomp.2006.03.004

DO - 10.1016/j.jdiacomp.2006.03.004

M3 - Journal article

C2 - 17825752

VL - 21

SP - 288

EP - 293

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 5

ER -

ID: 34076330