Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites
Research output: Contribution to journal › Journal article › Research › peer-review
Malaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations.
Original language | English |
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Journal | P L o S One |
Volume | 6 |
Issue number | 6 |
Pages (from-to) | e21711 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 1 Jan 2011 |
- Aging, Animals, Antibody Formation, Cluster Analysis, Humans, Infant, Malaria, Plasmodium falciparum, Principal Component Analysis, Protozoan Proteins, Serologic Tests, Time Factors
Research areas
ID: 35277228