Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains

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Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. / Kananen, L.; Enroth, L.; Raitanen, J.; Jylhava, J.; Buerkle, A.; Moreno-Villanueva, M.; Bernhardt, J.; Toussaint, O.; Grubeck-Loebenstein, B.; Malavolta, M.; Basso, A.; Piacenza, F.; Collino, S.; Gonos, E. S.; Sikora, E.; Gradinaru, D.; Jansen, E. H. J. M.; Dolle, M. E. T.; Salmon, M.; Stuetz, W.; Weber, D.; Grune, T.; Breusing, N.; Simm, A.; Capri, M.; Franceschi, C.; Slagboom, P. E.; Talbot, D. C. S.; Libert, C.; Koskinen, S.; Bruunsgaard, H.; Hansen, ÅM; Lund, R.; Hurme, M.; Jylha, M.

In: Scientific Reports, Vol. 11, No. 1, 6139, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kananen, L, Enroth, L, Raitanen, J, Jylhava, J, Buerkle, A, Moreno-Villanueva, M, Bernhardt, J, Toussaint, O, Grubeck-Loebenstein, B, Malavolta, M, Basso, A, Piacenza, F, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Jansen, EHJM, Dolle, MET, Salmon, M, Stuetz, W, Weber, D, Grune, T, Breusing, N, Simm, A, Capri, M, Franceschi, C, Slagboom, PE, Talbot, DCS, Libert, C, Koskinen, S, Bruunsgaard, H, Hansen, ÅM, Lund, R, Hurme, M & Jylha, M 2021, 'Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains', Scientific Reports, vol. 11, no. 1, 6139. https://doi.org/10.1038/s41598-021-85668-7

APA

Kananen, L., Enroth, L., Raitanen, J., Jylhava, J., Buerkle, A., Moreno-Villanueva, M., Bernhardt, J., Toussaint, O., Grubeck-Loebenstein, B., Malavolta, M., Basso, A., Piacenza, F., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Jansen, E. H. J. M., Dolle, M. E. T., Salmon, M., ... Jylha, M. (2021). Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. Scientific Reports, 11(1), [6139]. https://doi.org/10.1038/s41598-021-85668-7

Vancouver

Kananen L, Enroth L, Raitanen J, Jylhava J, Buerkle A, Moreno-Villanueva M et al. Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. Scientific Reports. 2021;11(1). 6139. https://doi.org/10.1038/s41598-021-85668-7

Author

Kananen, L. ; Enroth, L. ; Raitanen, J. ; Jylhava, J. ; Buerkle, A. ; Moreno-Villanueva, M. ; Bernhardt, J. ; Toussaint, O. ; Grubeck-Loebenstein, B. ; Malavolta, M. ; Basso, A. ; Piacenza, F. ; Collino, S. ; Gonos, E. S. ; Sikora, E. ; Gradinaru, D. ; Jansen, E. H. J. M. ; Dolle, M. E. T. ; Salmon, M. ; Stuetz, W. ; Weber, D. ; Grune, T. ; Breusing, N. ; Simm, A. ; Capri, M. ; Franceschi, C. ; Slagboom, P. E. ; Talbot, D. C. S. ; Libert, C. ; Koskinen, S. ; Bruunsgaard, H. ; Hansen, ÅM ; Lund, R. ; Hurme, M. ; Jylha, M. / Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

Bibtex

@article{1a66412810f844a68cf35f8c60e3e10f,
title = "Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains",
abstract = "Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different populations implies that it is a comprehensive measure of health status and may even reflect the condition of the human organism beyond clinical diagnoses. Yet the biological basis of SRH is poorly understood. We used data from three independent European population samples (N approx. 15,000) to investigate the associations of SRH with 150 biomolecules in blood or urine (biomarkers). Altogether 57 biomarkers representing different organ systems were associated with SRH. In almost half of the cases the association was independent of disease and physical functioning. Biomarkers weakened but did not remove the association between SRH and mortality. We propose three potential pathways through which biomarkers may be incorporated into an individual's subjective health assessment, including (1) their role in clinical diseases; (2) their association with health-related lifestyles; and (3) their potential to stimulate physical sensations through interoceptive mechanisms. Our findings indicate that SRH has a solid biological basis and it is a valid but non-specific indicator of the biological condition of the human organism.",
author = "L. Kananen and L. Enroth and J. Raitanen and J. Jylhava and A. Buerkle and M. Moreno-Villanueva and J. Bernhardt and O. Toussaint and B. Grubeck-Loebenstein and M. Malavolta and A. Basso and F. Piacenza and S. Collino and Gonos, {E. S.} and E. Sikora and D. Gradinaru and Jansen, {E. H. J. M.} and Dolle, {M. E. T.} and M. Salmon and W. Stuetz and D. Weber and T. Grune and N. Breusing and A. Simm and M. Capri and C. Franceschi and Slagboom, {P. E.} and Talbot, {D. C. S.} and C. Libert and S. Koskinen and H. Bruunsgaard and {\AA}M Hansen and R. Lund and M. Hurme and M. Jylha",
year = "2021",
doi = "10.1038/s41598-021-85668-7",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains

AU - Kananen, L.

AU - Enroth, L.

AU - Raitanen, J.

AU - Jylhava, J.

AU - Buerkle, A.

AU - Moreno-Villanueva, M.

AU - Bernhardt, J.

AU - Toussaint, O.

AU - Grubeck-Loebenstein, B.

AU - Malavolta, M.

AU - Basso, A.

AU - Piacenza, F.

AU - Collino, S.

AU - Gonos, E. S.

AU - Sikora, E.

AU - Gradinaru, D.

AU - Jansen, E. H. J. M.

AU - Dolle, M. E. T.

AU - Salmon, M.

AU - Stuetz, W.

AU - Weber, D.

AU - Grune, T.

AU - Breusing, N.

AU - Simm, A.

AU - Capri, M.

AU - Franceschi, C.

AU - Slagboom, P. E.

AU - Talbot, D. C. S.

AU - Libert, C.

AU - Koskinen, S.

AU - Bruunsgaard, H.

AU - Hansen, ÅM

AU - Lund, R.

AU - Hurme, M.

AU - Jylha, M.

PY - 2021

Y1 - 2021

N2 - Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different populations implies that it is a comprehensive measure of health status and may even reflect the condition of the human organism beyond clinical diagnoses. Yet the biological basis of SRH is poorly understood. We used data from three independent European population samples (N approx. 15,000) to investigate the associations of SRH with 150 biomolecules in blood or urine (biomarkers). Altogether 57 biomarkers representing different organ systems were associated with SRH. In almost half of the cases the association was independent of disease and physical functioning. Biomarkers weakened but did not remove the association between SRH and mortality. We propose three potential pathways through which biomarkers may be incorporated into an individual's subjective health assessment, including (1) their role in clinical diseases; (2) their association with health-related lifestyles; and (3) their potential to stimulate physical sensations through interoceptive mechanisms. Our findings indicate that SRH has a solid biological basis and it is a valid but non-specific indicator of the biological condition of the human organism.

AB - Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different populations implies that it is a comprehensive measure of health status and may even reflect the condition of the human organism beyond clinical diagnoses. Yet the biological basis of SRH is poorly understood. We used data from three independent European population samples (N approx. 15,000) to investigate the associations of SRH with 150 biomolecules in blood or urine (biomarkers). Altogether 57 biomarkers representing different organ systems were associated with SRH. In almost half of the cases the association was independent of disease and physical functioning. Biomarkers weakened but did not remove the association between SRH and mortality. We propose three potential pathways through which biomarkers may be incorporated into an individual's subjective health assessment, including (1) their role in clinical diseases; (2) their association with health-related lifestyles; and (3) their potential to stimulate physical sensations through interoceptive mechanisms. Our findings indicate that SRH has a solid biological basis and it is a valid but non-specific indicator of the biological condition of the human organism.

U2 - 10.1038/s41598-021-85668-7

DO - 10.1038/s41598-021-85668-7

M3 - Journal article

C2 - 33731775

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6139

ER -

ID: 258824217