Self‐Assembly of DNA–Peptide Supermolecules: Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity

Research output: Contribution to journal › Journal article › peer-review

Standard

Self‐Assembly of DNA–Peptide Supermolecules : Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity. / Lou, Chenguang; Boesen, Josephine Tuborg; Christensen, Niels Johan; Sørensen, Kasper K.; Thulstrup, Peter W.; Pedersen, Martin Nors; Giralt, Ernest; Jensen, Knud J.; Wengel, Jesper.

In: Chemistry: A European Journal, Vol. 26, No. 25, 2020, p. 5676-5684.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Lou, C, Boesen, JT, Christensen, NJ, Sørensen, KK, Thulstrup, PW, Pedersen, MN, Giralt, E, Jensen, KJ & Wengel, J 2020, 'Self‐Assembly of DNA–Peptide Supermolecules: Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity', Chemistry: A European Journal, vol. 26, no. 25, pp. 5676-5684. https://doi.org/10.1002/chem.201905636

APA

Lou, C., Boesen, J. T., Christensen, N. J., Sørensen, K. K., Thulstrup, P. W., Pedersen, M. N., Giralt, E., Jensen, K. J., & Wengel, J. (2020). Self‐Assembly of DNA–Peptide Supermolecules: Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity. Chemistry: A European Journal, 26(25), 5676-5684. https://doi.org/10.1002/chem.201905636

Vancouver

Lou C, Boesen JT, Christensen NJ, Sørensen KK, Thulstrup PW, Pedersen MN et al. Self‐Assembly of DNA–Peptide Supermolecules: Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity. Chemistry: A European Journal. 2020;26(25):5676-5684. https://doi.org/10.1002/chem.201905636

Author

Lou, Chenguang ; Boesen, Josephine Tuborg ; Christensen, Niels Johan ; Sørensen, Kasper K. ; Thulstrup, Peter W. ; Pedersen, Martin Nors ; Giralt, Ernest ; Jensen, Knud J. ; Wengel, Jesper. / Self‐Assembly of DNA–Peptide Supermolecules : Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity. In: Chemistry: A European Journal. 2020 ; Vol. 26, No. 25. pp. 5676-5684.

Bibtex

@article{8299bc3ade524628b387932cda6863ee,
title = "Self‐Assembly of DNA–Peptide Supermolecules: Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity",
abstract = "DNA nanostructures have been designed and used in many different applications. However, the use of nucleic acid scaffolds to promote the self‐assembly of artificial protein mimics is only starting to emerge. Herein five coiled‐coil peptide structures were templated by the hybridization of a d ‐DNA triplex or its mirror‐image counterpart, an l ‐DNA triplex. The self‐assembly of the desired trimeric structures in solution was confirmed by gel electrophoresis and small‐angle X‐ray scattering, and the stabilizing synergy between the two domains was found to be chirality‐independent but orientation‐dependent. This is the first example of using a nucleic acid scaffold of l ‐DNA to template the formation of artificial protein mimics. The results may advance the emerging POC‐based nanotechnology field by adding two extra dimensions, that is, chirality and polarity, to provide innovative molecular tools for rational design and bottom‐up construction of artificial protein mimics, programmable materials and responsive nanodevices.",
author = "Chenguang Lou and Boesen, {Josephine Tuborg} and Christensen, {Niels Johan} and S{\o}rensen, {Kasper K.} and Thulstrup, {Peter W.} and Pedersen, {Martin Nors} and Ernest Giralt and Jensen, {Knud J.} and Jesper Wengel",
year = "2020",
doi = "10.1002/chem.201905636",
language = "English",
volume = "26",
pages = "5676--5684",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "25",

}

RIS

TY - JOUR

T1 - Self‐Assembly of DNA–Peptide Supermolecules

T2 - Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity

AU - Lou, Chenguang

AU - Boesen, Josephine Tuborg

AU - Christensen, Niels Johan

AU - Sørensen, Kasper K.

AU - Thulstrup, Peter W.

AU - Pedersen, Martin Nors

AU - Giralt, Ernest

AU - Jensen, Knud J.

AU - Wengel, Jesper

PY - 2020

Y1 - 2020

N2 - DNA nanostructures have been designed and used in many different applications. However, the use of nucleic acid scaffolds to promote the self‐assembly of artificial protein mimics is only starting to emerge. Herein five coiled‐coil peptide structures were templated by the hybridization of a d ‐DNA triplex or its mirror‐image counterpart, an l ‐DNA triplex. The self‐assembly of the desired trimeric structures in solution was confirmed by gel electrophoresis and small‐angle X‐ray scattering, and the stabilizing synergy between the two domains was found to be chirality‐independent but orientation‐dependent. This is the first example of using a nucleic acid scaffold of l ‐DNA to template the formation of artificial protein mimics. The results may advance the emerging POC‐based nanotechnology field by adding two extra dimensions, that is, chirality and polarity, to provide innovative molecular tools for rational design and bottom‐up construction of artificial protein mimics, programmable materials and responsive nanodevices.

AB - DNA nanostructures have been designed and used in many different applications. However, the use of nucleic acid scaffolds to promote the self‐assembly of artificial protein mimics is only starting to emerge. Herein five coiled‐coil peptide structures were templated by the hybridization of a d ‐DNA triplex or its mirror‐image counterpart, an l ‐DNA triplex. The self‐assembly of the desired trimeric structures in solution was confirmed by gel electrophoresis and small‐angle X‐ray scattering, and the stabilizing synergy between the two domains was found to be chirality‐independent but orientation‐dependent. This is the first example of using a nucleic acid scaffold of l ‐DNA to template the formation of artificial protein mimics. The results may advance the emerging POC‐based nanotechnology field by adding two extra dimensions, that is, chirality and polarity, to provide innovative molecular tools for rational design and bottom‐up construction of artificial protein mimics, programmable materials and responsive nanodevices.

U2 - 10.1002/chem.201905636

DO - 10.1002/chem.201905636

M3 - Journal article

C2 - 32022377

VL - 26

SP - 5676

EP - 5684

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

IS - 25

ER -

ID: 240196929