Secondary hyperparathyroidism of morbid obesity regresses during weight reduction
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Secondary hyperparathyroidism of morbid obesity regresses during weight reduction. / Andersen, T; McNair, P; Hyldstrup, L; Fogh-Andersen, N; Nielsen, T T; Astrup, Arne; Transbøl, I.
In: Metabolism, Vol. 37, No. 5, 1988, p. 425-428.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Secondary hyperparathyroidism of morbid obesity regresses during weight reduction
AU - Andersen, T
AU - McNair, P
AU - Hyldstrup, L
AU - Fogh-Andersen, N
AU - Nielsen, T T
AU - Astrup, Arne
AU - Transbøl, I
PY - 1988
Y1 - 1988
N2 - In order to test the relation between obesity and the secondary hyperparthyroidism found in markedly overweight subjects, 24 morbidly obese patients were studied before and after a weight loss of 35.9 kg obtained by a nutritionally adequate, intermittent very-low-calorie diet. Overweight was reduced from 98 ± 34% to 44 ± 19%. Serum total calcium did not change, but serum ionized calcium (Ca2+) increased from 1.22 ± 0.04 mmol/L to 1.25 ± 0.04 mmol/L (P < .001). A corresponding fall was observed in serum parathyroid hormone (s-PTH), which decreased from 47.2 ± 21.7 pmol/L to 35.2 ± 19.4 pmol/L (P = .01). The change of s-PTH was positively associated with the reduction of body weight (r = .50, P < .05) and with the reduction of overweight (r = .55, P < .01). Regarding calcium binding substances, serum albumin remained low. The initially lowered serum phosphate and bicarbonate both rose (P < .001). Plasma lactate and plasma free fatty acids (FFAs) decreased (P < .001). The study supports our hypothesis that the changed profile of calcium complexing anions in obesity interferes with the tubular reabsorption of calcium, which in turn lowers serum Ca2+, thus promoting hyperparathyroidism. Along with weight loss, concentrations of calcium complexing anions returns towards normal values and the secondary hyperparathyroidism regresses.
AB - In order to test the relation between obesity and the secondary hyperparthyroidism found in markedly overweight subjects, 24 morbidly obese patients were studied before and after a weight loss of 35.9 kg obtained by a nutritionally adequate, intermittent very-low-calorie diet. Overweight was reduced from 98 ± 34% to 44 ± 19%. Serum total calcium did not change, but serum ionized calcium (Ca2+) increased from 1.22 ± 0.04 mmol/L to 1.25 ± 0.04 mmol/L (P < .001). A corresponding fall was observed in serum parathyroid hormone (s-PTH), which decreased from 47.2 ± 21.7 pmol/L to 35.2 ± 19.4 pmol/L (P = .01). The change of s-PTH was positively associated with the reduction of body weight (r = .50, P < .05) and with the reduction of overweight (r = .55, P < .01). Regarding calcium binding substances, serum albumin remained low. The initially lowered serum phosphate and bicarbonate both rose (P < .001). Plasma lactate and plasma free fatty acids (FFAs) decreased (P < .001). The study supports our hypothesis that the changed profile of calcium complexing anions in obesity interferes with the tubular reabsorption of calcium, which in turn lowers serum Ca2+, thus promoting hyperparathyroidism. Along with weight loss, concentrations of calcium complexing anions returns towards normal values and the secondary hyperparathyroidism regresses.
U2 - 10.1016/0026-0495(88)90041-8
DO - 10.1016/0026-0495(88)90041-8
M3 - Journal article
C2 - 3367788
AN - SCOPUS:0023901587
VL - 37
SP - 425
EP - 428
JO - Metabolism
JF - Metabolism
SN - 0026-0495
IS - 5
ER -
ID: 212165133