Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. / Indo, Hiroko P.; Hawkins, Clare L; Nakanishi, Ikuo; Matsumoto, Ken-Ichiro; Matsui, Hirofumi; Suenaga, Shigeaki; Davies, Michael J; St Clair, Daret K; Ozawa, Toshihiko; Majima, Hideyuki J.

Pharmacology of Mitochondria. Vol. 240 Springer, 2017. p. 439-456 (Handbook of Experimental Pharmacology, Vol. 240).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Harvard

Indo, HP, Hawkins, CL, Nakanishi, I, Matsumoto, K-I, Matsui, H, Suenaga, S, Davies, MJ, St Clair, DK, Ozawa, T & Majima, HJ 2017, Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. in Pharmacology of Mitochondria. vol. 240, Springer, Handbook of Experimental Pharmacology, vol. 240, pp. 439-456. https://doi.org/10.1007/164_2016_117

APA

Indo, H. P., Hawkins, C. L., Nakanishi, I., Matsumoto, K-I., Matsui, H., Suenaga, S., ... Majima, H. J. (2017). Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. In Pharmacology of Mitochondria (Vol. 240, pp. 439-456). Springer. Handbook of Experimental Pharmacology, Vol.. 240 https://doi.org/10.1007/164_2016_117

Vancouver

Indo HP, Hawkins CL, Nakanishi I, Matsumoto K-I, Matsui H, Suenaga S et al. Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. In Pharmacology of Mitochondria. Vol. 240. Springer. 2017. p. 439-456. (Handbook of Experimental Pharmacology, Vol. 240). https://doi.org/10.1007/164_2016_117

Author

Indo, Hiroko P. ; Hawkins, Clare L ; Nakanishi, Ikuo ; Matsumoto, Ken-Ichiro ; Matsui, Hirofumi ; Suenaga, Shigeaki ; Davies, Michael J ; St Clair, Daret K ; Ozawa, Toshihiko ; Majima, Hideyuki J. / Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function. Pharmacology of Mitochondria. Vol. 240 Springer, 2017. pp. 439-456 (Handbook of Experimental Pharmacology, Vol. 240).

Bibtex

@inbook{cf38d1dbb5db4e379e6c5fb3287920c1,
title = "Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function",
abstract = "Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.",
keywords = "Journal Article",
author = "Indo, {Hiroko P.} and Hawkins, {Clare L} and Ikuo Nakanishi and Ken-Ichiro Matsumoto and Hirofumi Matsui and Shigeaki Suenaga and Davies, {Michael J} and {St Clair}, {Daret K} and Toshihiko Ozawa and Majima, {Hideyuki J.}",
year = "2017",
doi = "10.1007/164_2016_117",
language = "English",
isbn = "978-3-319-57311-3",
volume = "240",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer",
pages = "439--456",
booktitle = "Pharmacology of Mitochondria",

}

RIS

TY - CHAP

T1 - Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

AU - Indo, Hiroko P.

AU - Hawkins, Clare L

AU - Nakanishi, Ikuo

AU - Matsumoto, Ken-Ichiro

AU - Matsui, Hirofumi

AU - Suenaga, Shigeaki

AU - Davies, Michael J

AU - St Clair, Daret K

AU - Ozawa, Toshihiko

AU - Majima, Hideyuki J.

PY - 2017

Y1 - 2017

N2 - Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.

AB - Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.

KW - Journal Article

U2 - 10.1007/164_2016_117

DO - 10.1007/164_2016_117

M3 - Book chapter

C2 - 28176043

SN - 978-3-319-57311-3

VL - 240

T3 - Handbook of Experimental Pharmacology

SP - 439

EP - 456

BT - Pharmacology of Mitochondria

PB - Springer

ER -

ID: 182331246